Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Grafting-density-controlled superhydrophilic chitosan-graft-poly(carboxybetaine methacrylate) coatings for protein-resistant biointerfaces
Δημιουργός/Συγγραφέας:	Sentoukas, Theodore Marcinkowski, Andrzej Wałach, Wojciech Olszowska, Karolina [EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Trzebicka, Barbara
Ημερομηνία:	2027
Γλώσσα:	Αγγλικά
ISSN:	01694332
DOI:	10.1016/j.apsusc.2026.168516
Περίληψη:	Chitosan is a renewable and chemically versatile biopolymer, but its use in fouling-prone environments is limited by its tendency to interact with proteins and other biological species. In this work, chains of superhydrophilic zwitterionic poly(carboxybetaine methacrylate) (PCBMA) were grafted onto chitosan to improve its surface hydration and protein resistance. PCBMA homopolymers with different molar masses were synthesized by RAFT polymerization and then grafted onto chitosan using a grafting-to approach. The grafting behavior depended strongly on PCBMA chain length: shorter PCBMA chains led to higher grafting density, while longer chains resulted in lower substitution because of increased steric limitations. CS and CS-g-PCBMA copolymers were then deposited as thin films on silicon oxide wafers by spin coating to evaluate surface morphology, wettability, and protein fouling. The retention of protein was studied with bovine serum albumin (BSA) as model protein. Τhis study showed that length and grafting density of PCBMA control the surface properties of CS-g-PCBMA thin films. Thin films produced from densely grafted CS with short PCBMA chains led to smooth, highly wettable, and protein-resistant chitosan-based coatings. These findings provide a useful strategy for designing hydrated, polysaccharide-based zwitterionic surfaces for antifouling applications.
Τίτλος πηγής δημοσίευσης:	Applied Surface Science
Τόμος/Κεφάλαιο:	754
Θεματική Κατηγορία:	[EL] Βιοιατρική μηχανική. Ηλεκτρονική. Ενοργάνιση[EN] Biomedical engineering. Electronics. Instrumentation [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	chitosan PCBMA super hydrophilic polymers Thin-films antifouling biointerfaces
Κάτοχος πνευματικών δικαιωμάτων:	© 2026 The Author(s). Published by Elsevier B.V.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.apsusc.2026.168516
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο