Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	INSIGHT: An integrated framework for safe and sustainable chemical and material assessment
Δημιουργός/Συγγραφέας:	Serra, Angela Zouraris, Dimitrios Schaffert, Alexandra Torres Maia, Marcella Tsiros, Periklis Virmani, Ishita Di Lieto, Emanuele Saarimäki, Laura Aliisa Morikka, Jack Riudavets-Puig, Rafael Varsou, Dimitra-Danai Papavasileiou, Konstantinos D Kolokathis, Panagiotis D Mintis, Dimitris G Tzoupis, Haralampos Tsoumanis, Andreas Melagraki, Georgia Arvanitidis, Alex Doganis, Philip Minadakis, Vasileios Savvas, Giannis Perello-Y-Bestard, Adrien Cucurachi, Stefano Buljan, Marija Nikiforou, Fotini Karakoltzidis, Achilleas [EL] Καρακίτσιος, Σπύρος[EN] Karakitsios, Spyros [EL] Σαρηγιάννης, Δημοσθένης[EN] Sarigiannis, Dimosthenis Friedrichs, Steffi Seitz, Christian Gutierrez, Tomas Navarrete Isigonis, Panagiotis Cambier, Sébastien Marvuglia, Antonino Lindner, Gottlieb Georg Sergent, Jacques-Aurélien Gheorghe, L Cristiana Bradford, Laura-Jayne A Park, Seung-Geun Ha, Seung Min Gerelkhuu, Zayakhuu Yoon, Tae Hyun Petry, Romana Martinez, Diego Stéfani Teodoro Winkler, David A Wick, Peter Exner, Thomas E Dondero, Francesco Serchi, Tommaso Peijnenburg, Willie Sarimveis, Haralambos Paparella, Martin Lynch, Iseult Afantitis, Antreas Greco, Dario
Ημερομηνία:	2025
Γλώσσα:	Αγγλικά
ISSN:	2001-0370
DOI:	10.1016/j.csbj.2025.03.042
Άλλο:	40241814
Περίληψη:	The assessment of chemicals and materials has traditionally been fragmented, with health, environmental, social, and economic impacts evaluated independently. This disjointed approach limits the ability to capture trade-offs and synergies necessary for comprehensive decision-making under the Safe and Sustainable by Design (SSbD) framework. The EU INSIGHT project addresses this challenge by developing a novel computational framework for integrated impact assessment, based on the Impact Outcome Pathway (IOP) approach. Extending the Adverse Outcome Pathway (AOP) concept, IOPs establish mechanistic links between chemical and material properties and their environmental, health, and socio-economic consequences. The project integrates multi-source datasets (including omics, life cycle inventories, and exposure models) into a structured knowledge graph (KG), ensuring FAIR (Findable, Accessible, Interoperable, Reusable) data principles are met. INSIGHT is being developed and validated through four case studies targeting per- and polyfluoroalkyl substances (PFAS), graphene oxide (GO), bio-based synthetic amorphous silica (SAS), and antimicrobial coatings. These studies demonstrate how multi-model simulations, decision-support tools, and artificial intelligence-driven knowledge extraction can enhance the predictability and interpretability of chemical and material impacts. Additionally, INSIGHT incorporates interactive, web-based decision maps to provide stakeholders with accessible, regulatory-compliant risk and sustainability assessments. By bridging mechanistic toxicology, exposure modeling, life cycle assessment, and socio-economic analysis, INSIGHT advances a scalable, transparent, and data-driven approach to SSbD. This project aligns with the European Green Deal and global sustainability goals, promoting safer, more sustainable innovation in chemicals and materials through an integrated, mechanistic, and computationally advanced framework.
Τίτλος πηγής δημοσίευσης:	Computational and structural biotechnology journal
Τόμος/Κεφάλαιο:	29
Θεματική Κατηγορία:	[EL] Επιστήμες περιβάλλοντος[EN] Environmental sciences [EL] Τοξικολογία[EN] Toxicology. Poisons [EL] Πληροφορική[EN] Information technology
Λέξεις-Κλειδιά:	Chemical and material risk assessment FAIR principles Impact outcome pathway (IOP) Non-animal or new approach methods (NAMs) Safe and sustainable by design (SSbD)
Χρηματοδότης:	European Union, European Health and Digital Executive Agency (HADEA) UK Research and Innovation (UKRI) – Innovate UK State Secretariat for Education, Research and Innovation (SERI) National Research Foundation of Korea (NRF)
Χρηματοδοτικό πρόγραμμα:	Horizon Europe, INSIGHT programme
Αναγνωριστικό χρηματοδοτικού προγράμματος:	101137742 10097888 24.00030 RS-2024-00452934 2020R1A6A1A06046728
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.csbj.2025.03.042
Σημειώσεις:	INSIGHT (Grant Agreement No. 101137742) is co-funded by the European Union’s Horizon Europe programme under the call HORIZON-CL4–2023-RESILIENCE-01, managed by the European Health and Digital Executive Agency (HADEA), with a total grant of €4,130,318.75 supporting the project from January 2024 to December 2027. Co-funding from UKRI Innovate UK for UoB participation via grant no. 10097888. EMPA also acknowledge the State Secretariat for Education, Research and Innovation (SERI) no 24.00030. Nano Material Technology Development Program (Grant number RS-2024–00452934) and Basic Science Research Program (Grant number 2020R1A6A1A06046728) through the National Research Foundation of Korea (NRF).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο