Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review
Δημιουργός/Συγγραφέας:	Arca-Lafuente, Sonia Nuñez-Corcuera, Beatriz Ramis, Rebeca [EL] Καρακίτσιος, Σπύρος[EN] Karakitsios, Spyros [EL] Σαρηγιάννης, Δημοσθένης[EN] Sarigiannis, Dimosthenis García Dos Santos, Saúl Fernández-Rodríguez, Amanda Briz, Verónica
Ημερομηνία:	2025-03-28
Γλώσσα:	Αγγλικά
ISSN:	1465-993X
DOI:	10.1186/s12931-025-03179-9
Άλλο:	40156019
Περίληψη:	Exposure to air pollutants has a direct impact on human health, resulting in increased mortality rates. Airborne particulate matter (PM) has major adverse effects on health and can be classified as high-risk respiratory particles (fine/PM2.5, aerodynamic diameter < 2.5 µm) or thoracic particles (coarse/PM10, aerodynamic diameter < 10 µm). In addition, airborne PM can carry microbial communities that alter the commensal microbiota and lead to dysbiosis. Our aim was to synthesize the current research evidence describing the association between air pollution exposure and the microbiome composition of the upper respiratory tract (URT) of the adult population. In this work, a systematic search of the PubMed, EMBASE and Scopus databases was conducted. A total of 9 studies published from 2018 to 2023 were included. 66.5% of the participants were exposed to PM2.5 concentrations higher than 40 µg/m3, and data showed that PM2.5 atmospheric levels were positively correlated with PM10 (rs = 0.95, p < 0.001). All the reviewed studies performed 16S rRNA sequencing of the V3-V4 region from URT samples, using different methods. Overall, evidence of URT microbiome alterations after high PM exposure was observed, with seasonal and geographical influence. Discordant findings were found about bacterial diversity, with a predominant decrease after exposure to high PM levels. Regarding microbiome composition, the relative abundance of the Actinobacteria phylum declined following exposure to high levels of PM, but that of Bacteroidetes and Fusobacteria increased. The studies showed a low-middle risk of bias due to heterogeneity regarding sample processing, sequencing methods, and confounder control. To confirm the observed evidence of an association between PM levels and alterations in the URT microbiome, we strongly recommend that future research work be conducted in accordance with standard guidelines for reporting microbiome studies. In summary, the entry of fine and coarse particles into the URT is associated with microbial dysbiosis, increasing the risk of developing respiratory diseases and allergies.Prospero registration: This systematic review was registered on PROSPERO (#CRD42023416230).
Τίτλος πηγής δημοσίευσης:	Respiratory research
Τόμος/Κεφάλαιο:	26
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Περιβαλλοντική υγεία[EN] Environmental health [EL] Μικροβιολογία[EN] Microbiology [EL] Δημόσια υγεία. Υγιεινή. Προληπτική ιατρική[EN] Public health. Hygiene. Preventive medicine
Λέξεις-Κλειδιά:	Dysbiosis Microbiome PM10 PM2.5 Upper respiratory tract
Χρηματοδότης:	European Union
Χρηματοδοτικό πρόγραμμα:	European H2020 project URBANOME Europe Horizon project ENVESOME
Αναγνωριστικό χρηματοδοτικού προγράμματος:	945391 101157269
Κάτοχος πνευματικών δικαιωμάτων:	The Author(s) 2025.
Όροι και προϋποθέσεις δικαιωμάτων:	Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1186/s12931-025-03179-9
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο