Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	A comprehensive library of lifetime physiological equations for PBK models: Enhancing dietary exposure modeling with mercury as a case study
Δημιουργός/Συγγραφέας:	Gastellu, Thomas Karakoltzidis, Achilleas Ratier, Aude Bellouard, Marie Alvarez, Jean-Claude Le Bizec, Bruno Rivière, Gilles [EL] Καρακίτσιος, Σπύρος[EN] Karakitsios, Spyros [EL] Σαρηγιάννης, Δημοσθένης[EN] Sarigiannis, Dimosthenis Vogs, Carolina
Ημερομηνία:	2025-01-15
Γλώσσα:	Αγγλικά
ISSN:	00139351
DOI:	10.1016/j.envres.2024.120393
Άλλο:	39579851
Περίληψη:	Dietary risk assessment of food contaminants requires a well-established understanding of the exposure in a heterogeneous population. There are many methods for estimating human exposure to food contaminants, such as intake calculations and internal biomarkers of exposure measured in individuals. However, those methods are expensive, partly invasive, and often provide a momentary exposure snapshot. Physiologically Based Kinetic (PBK) modelling is increasingly used to overcome those challenges that traditional human exposure methods encounter. Still, PBK models are often restricted to certain life stages (e.g., children, adolescents, adults). This study outlines a strategy for implementing nonlinear organ growths in age-specific PBK models to enhance dietary risk assessment from lifetime exposure. To this end, lifetime physiological equations calculating organ growth for both sexes were inventoried from literature and a library was established for 24 organs. We then assessed total lifelong mercury exposure via foodstuff by combining two existing age-specific PBK models for methylmercury (MeHg) and inorganic mercury (iHg) that simulated internal exposure to total mercury, the speciation typically measured in hair and urine. We implemented a set of physiological equations in the PBK model that fitted best the total mercury measured in individuals' organs, hair, and urine from heterogeneous populations. For refined dietary risk assessment, we ultimately estimated total mercury concentration in hair and urine based on i) maximum limits defined by the regulation for MeHg in seafood, ii) the health-based guidance values for MeHg and iHg, and iii) realistic intakes considering French demographic parameters and food consumption data. These exposure scenarios demonstrated that total mercury concentrations in hair and urine estimated from realistic intakes are below critical effect level measures at all ages. The result of this study is the creation of easily accessible tools in Excel and R that facilitate the implementation of physiological equations in Next Generation PBK models.
Τίτλος πηγής δημοσίευσης:	Environmental research
Τόμος/Κεφάλαιο:	265
Θεματική Κατηγορία:	[EL] Δημόσια υγεία. Υγιεινή. Προληπτική ιατρική[EN] Public health. Hygiene. Preventive medicine [EL] Τοξικολογία[EN] Toxicology. Poisons [EL] Περιβαλλοντική υγεία[EN] Environmental health [EL] Πληροφορική[EN] Information technology
Λέξεις-Κλειδιά:	ADME toxicokinetics Lifetime dietary exposure Toxicological reference values total mercury
Χρηματοδότης:	European Union FORMAS a Swedish council
Χρηματοδοτικό πρόγραμμα:	European Union's Horizon Europe research and innovation programme, PARC project
Αναγνωριστικό χρηματοδοτικού προγράμματος:	101057014 2023-00591
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 The Authors. Published by Elsevier Inc.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.envres.2024.120393
Σημειώσεις:	This project has received funding from the European Partnership for the Assessment of Risks from Chemicals (PARC project) founded by the European Union's Horizon Europe research and innovation programme under Grant Agreement No 101057014, and from FORMAS a Swedish council for sustainable development [Grant No 2023-00591]. This study was supported by ANSES and INRAE (thesis scholarship co-financing agreement).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο