Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Preparation and evaluation of mixed alginate-cyclodextrin hydrogels: From physicochemical, thermotropic to swelling characterization
Δημιουργός/Συγγραφέας:	Karali, Vasiliki Goula, Paraskevi-Evelina Patroklou, Georgia Saitani, Elmina-Marina Baltatzis, George E. Gatou, Maria-Anna Kontaxis, Lykourgos C. Pavlatou, Evangelia A. Zaoutsos, Stefanos P. Trougakos, Ioannis Valsami, Georgia Pippa, Natassa [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Ημερομηνία:	2025
Γλώσσα:	Αγγλικά
ISSN:	09277757
DOI:	10.1016/j.colsurfa.2025.137199
Περίληψη:	The aim of this study is to develop hydrogel beads with the addition of cyclodextrins into a sodium alginate matrix and examine their swelling properties in different pH conditions. To achieve this, Methyl-β-Cyclodextrin (M-β-CD) and Hydroxypropyl-β-Cyclodextrin (HP-β-CD) were mixed with sodium alginate solution to form hydrogel beads. The formation of these beads was achieved at two different dropping distances (15 cm and 25 cm), and their swelling behavior was evaluated in two pH environments: SGF (simulated gastric fluid, pH 1.2) and SIF (simulated intestinal fluid, pH 6.8). The thermotropic behavior of the prepared alginate-based beads was analyzed using Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). Scanning Electron Microscopy (SEM) was employed to evaluate the impact of the preparation method and the presence of different types of cyclodextrins (CDs) on the beads' morphological characteristics. Results indicated that the addition of CDs had a substantial impact on the beads’ swelling behavior and morphology, with HP-β-CD beads demonstrating the highest disintegration rate in SIF, mostly due to greater hydrophilicity and matrix interactions. The beads with CDs that were prepared at higher dropping distance exhibited increased porosity, enhancing water absorption. This study highlights the impact of CDs’ coexistence on the pH-responsiveness of alginate-based hydrogels, underscoring their potential as delivery platforms for controlled drug release systems.
Τίτλος πηγής δημοσίευσης:	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Τόμος/Κεφάλαιο:	721
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φαρμακευτική[EN] Pharmacy and materia medica
Λέξεις-Κλειδιά:	hydrogels swelling ph-responsiveness alginate cyclodextrins
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Author(s). Published by Elsevier B.V.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.colsurfa.2025.137199
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο