Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	The Ubiquitous Use of Polyethylene Glycol in Pharmaceutical Design and Development: Technological Aspects and Future Perspectives
Δημιουργός/Συγγραφέας:	Christoforou, Iliana Kalatzis, Anastasios Siamidi, Angeliki Vlachou, Marilena [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Pippa, Natassa
Ημερομηνία:	2025-11-24
Γλώσσα:	Αγγλικά
ISSN:	2079-4991
DOI:	10.3390/nano15231762
Άλλο:	41369439
Περίληψη:	Polyethylene glycol (PEG) has been extensively utilized in drug formulations due to its multifunctional properties, i.e., hydrophilicity and biocompatibility. The roles played by PEG (as a drug delivery carrier and a solubilizer) improve the dissolution profile of several active pharmaceutical ingredients (APIs), leading to an improved absorption, distribution, metabolism, excretion, and toxicity (ADMET) profile. Moreover, PEG aids in upgrading the existing mechanical properties (as a binding agent, a plasticizer, etc.). Furthermore, PEG, due to its unique ability to provide "stealth" properties, is a valuable tool in pharmaceutical nanotechnology. Exploiting physicochemical variables, PEG acts as a coating/conjugation component of nanocarriers for ameliorating permeability and enhancing in vivo circulation without clearance by the body's immune system. Additionally, PEG's presence at the target site decreases external interactions and enhances the pharmacological attributes in terms of loading efficiency and controlled release. Nevertheless, cases of hypersensitivity or allergy, as well as anaphylactic shocks and allergic reactions, have been detected. The topic of this article is the exploitation of PEG's physicochemical properties in the study of drug delivery, focusing on solid dosage forms and nanovesicles, along with the evaluation of its contribution to the fabrication of safe delivery and theragnostic systems.
Τίτλος πηγής δημοσίευσης:	Nanomaterials (Basel, Switzerland)
Τόμος/Κεφάλαιο:	15
Τεύχος:	23
Θεματική Κατηγορία:	[EL] Φαρμακευτική[EN] Pharmacy and materia medica [EL] Νανοτεχνολογία[EN] Nanotechnology
Λέξεις-Κλειδιά:	PEG active pharmaceutical ingredient drug delivery drug release hydrophilicity nanocarriers solid dosage forms
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/nano15231762
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο