Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	pH and Temperature Dependence of Low‐Core Tg Micellar Structures Formed by PDMAEMA‐b‐PLMA Diblock Copolymers in Aqueous Solution
Δημιουργός/Συγγραφέας:	Chrysostomou, Varvara Da Vela, Stefano [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Papadakis, Christine M.
Ημερομηνία:	2025
Γλώσσα:	Αγγλικά
ISSN:	2642-4150 2642-4169
DOI:	10.1002/pol.20241120
Περίληψη:	A diblock copolymer featuring a hydrophobic block with a low glass transition temperature and a pH-responsive, cationic blockis synthesized and investigated with respect to its self-assembly behavior in aqueous solution. The synthesis of the poly(laurylmethacrylate)-block-poly(2- (N,N-dimethylamino) ethyl methacrylate) diblock copolymer PDMAEMA 60 -b- PLMA 40 is carried outusing reversible addition fragmentation chain transfer (RAFT) polymerization. Its self-assembly in dilute aqueous solution atpH 7 is investigated using various light scattering methods. Micelles with a positive zeta potential are identified. Synchrotronsmall-angle X-ray scattering reveals changes in the inner structure of the micelles as a function of temperature and at pH valuesabove, below and close to the pKa value of PDMAEMA (ca. 7.5). At all pH values, cigar-shaped core–shell micelles are found.While the micellar size and shape hardly change with temperature at pH 5, temperature responsivity is observed at pH 7 and 10,resulting in, among others, a change of the core size. These structural changes are facilitated by the softness of the PLMA core.Such systems may be suitable for the co-delivery of hydrophobic drugs and nucleic acids.
Τίτλος πηγής δημοσίευσης:	Journal of Polymer Science
Τόμος/Κεφάλαιο:	63
Τεύχος:	7
Σελίδες:	1519-1747
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	amphiphilic block copolymers light scattering self-assembly synchrotron small-angle X-ray scattering
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Author(s). Journal of Polymer Science published by Wiley Periodicals LLC.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1002/pol.20241120
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο