Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Advanced P407/Tw80/βCD based Nasal Powders of Ropinirole Hydrochloride for Nose-to-Brain Delivery in Parkinson's Disease: Preparation and Comprehensive In Vitro and Ex Vivo Evaluation
Δημιουργός/Συγγραφέας:	Saitani, Elmina-Marina Papakyriakopoulou, Paraskevi Kikionis, Stefanos Pippa, Natassa [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Valsami, Georgia
Ημερομηνία:	2025-09-18
Γλώσσα:	Αγγλικά
ISSN:	1550-7416
DOI:	10.1208/s12248-025-01128-4
Άλλο:	40968216
Περίληψη:	This study focuses on the development of lyophilized nasal powders of ropinirole hydrochloride (RH), composed of Poloxamer 407 triblock copolymer (P407), surfactant Tween 80 (Tw80) and derivatives of βCD [methyl-β-CD (MβCD) or hydroxy-propyl-β-CD (HPβCD)] for managing Parkinson's disease. The lyophilized compositions were produced by freeze-drying of the corresponding colloidal dispersions. The innovative aspect of this research lies in the integration of these diverse biomaterials to develop advanced drug delivery systems for nasal administration. The optimal lyophilized formulations were blended with spray-dried microparticles of mannitol and lecithin (MLMPs) in various ratios. The blending process resulted in powders with improved morphological characteristics, as evidenced by Scanning Electron Microscopy analysis. Nasal powders were characterized through in vitro diffusion and ex vivo permeation studies. Finally, a comparison between the nasal powders and the corresponding colloidal dispersions was held. Results showed that the lyophilized powders had a superior release profile compared to colloidal dispersions, and blending with MPMPs further enhanced this effect. Ex vivo powders' permeation across rabbit nasal mucosa was found to be more efficient compared to pure RH solution. In particular, the lyophilized formulation of (P407/Tw80/HPβCD)/RH 10:5 blended with MLMPs (25:75) achieved 54.40 ± 3.30% permeation of the loading dose and a mass balance of 98.15 ± 1.61%. This study demonstrates the potential of these formulations for effective nose-to-brain drug delivery. Ongoing in vivo pharmacokinetic studies are being conducted to assess the performance of the optimal formulations in an appropriate animal model.
Τίτλος πηγής δημοσίευσης:	The AAPS journal
Τόμος/Κεφάλαιο:	27
Τεύχος:	6
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Νανοτεχνολογία[EN] Nanotechnology
Λέξεις-Κλειδιά:	nasal powders nose-to-brain delivery poloxamer 407 triblock copolymer cyclodextrins ropinirole hydrochloride
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists 2025
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1208/s12248-025-01128-4
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο