Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Lipid/copolymer hybrid drug delivery systems: From design to performance
Δημιουργός/Συγγραφέας:	Triantafyllopoulou, Efstathia Selianitis, Dimitrios Chountoulesi, Maria Karayianni, Maria Valsami, Georgia [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Pippa, Natassa
Ημερομηνία:	2026-03-30
Γλώσσα:	Αγγλικά
ISSN:	00018686
DOI:	10.1016/j.cis.2026.103884
Άλλο:	41923680
Περίληψη:	In recent years, nanomedicine has become very popular in the pharmaceutical field as it raises opportunities for precise and more effective pharmacotherapy. Among others, hybrid lipid/polymer systems have gained a lot of interest as drug delivery nanoplatforms having several assets: combine the advantages of both lipid- and polymer- based nanoparticles, minimize the drawbacks, and exhibit new inherent properties. This review summarizes the most recent studies on hybrid nanostructures comprised of phospholipids and copolymers for drug and gene delivery. The general aspects of lipids and polymers alongside the formulation protocols, the characterization techniques, and the applications of hybrid systems are reported as well. From a critical point of view, the complexity of hybrids and their added value are considered, while the critical quality attributes as well as the still existing limitations are also highlighted. Embracing the quality by design-oriented formulation strategy, this work could, hopefully, enlighten the design and development of safe and efficient lipid/copolymer nanoparticles from a technological perspective having as the ultimate goal their clinical application.
Τίτλος πηγής δημοσίευσης:	Advances in colloid and interface science
Τόμος/Κεφάλαιο:	353
Θεματική Κατηγορία:	[EL] Φαρμακευτική τεχνολογία[EN] Pharmaceutical technology [EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Βιοιατρική μηχανική. Ηλεκτρονική. Ενοργάνιση[EN] Biomedical engineering. Electronics. Instrumentation [EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology
Λέξεις-Κλειδιά:	Clinical translation Copolymer Critical quality attributes Drug delivery systems Hybrid nanoparticles Pharmaceutical technology Phospholipid
Κάτοχος πνευματικών δικαιωμάτων:	© 2026 The Authors. Published by Elsevier B.V.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.cis.2026.103884
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο