Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Co-Encapsulation of Phycocyanin and Albumin-Bound Curcumin in Biopolymeric Hydrogels
Δημιουργός/Συγγραφέας:	Matskou, Konstantina Matis, Ilias Demisli, Sotiria Rigkos, Konstantinos Karandrea, Eirini Kourioti, Kalliopi [EL] Σωτηρούδης, Γιώργος[EN] Sotiroudis, Georgios [EL] Πλέτσα, Βασιλική[EN] Pletsa, Vassiliki [EL] Ξενάκης, Αριστοτέλης[EN] Xenakis, Aristotelis [EL] Ζουμπανιώτη, Μαρία[EN] Zoumpanioti, Maria
Ημερομηνία:	2025-04-17
Γλώσσα:	Αγγλικά
ISSN:	1422-0067
DOI:	10.3390/ijms26083805
Άλλο:	40332428
Περίληψη:	Co-encapsulation of hydrophilic and hydrophobic compounds within a single delivery system remains a significant challenge across various scientific and industrial fields. Towards this direction, an encapsulation strategy is proposed, enabling the simultaneous incorporation of both hydrophilic and hydrophobic biomolecules within a hydrogel matrix. Specifically, the cyanobacterial protein phycocyanin (hydrophilic), extracted and purified by dry Arthrospira maxima biomass, and curcumin (hydrophobic) bound to bovine serum albumin (BSA) were utilized. This approach facilitates the indirect entrapment of hydrophobic molecules within the hydrophilic hydrogel network. The structural and physicochemical properties of the resulting hydrogels were characterized using optical analysis, scanning electron microscopy (SEM), and confocal laser scanning microscopy (CLSM). Additionally, the antioxidant potential of the encapsulated biomolecules was evaluated to assess their functionality after the encapsulation. Furthermore, a cell viability assay confirmed the hydrogel's biocompatibility and lack of toxicity, demonstrating its suitability as a multifunctional biomaterial for biomedical and pharmaceutical applications.
Τίτλος πηγής δημοσίευσης:	International journal of molecular sciences
Τόμος/Κεφάλαιο:	26
Τεύχος:	8
Θεματική Κατηγορία:	[EL] Φαρμακευτική τεχνολογία[EN] Pharmaceutical technology [EL] Βιοτεχνολογία[EN] Biotechnology [EL] Βιοιατρική μηχανική. Ηλεκτρονική. Ενοργάνιση[EN] Biomedical engineering. Electronics. Instrumentation [EL] Νανοτεχνολογία[EN] Nanotechnology
Λέξεις-Κλειδιά:	antioxidants biopolymers cell viability hydrogels morphology structure
Χρηματοδότης:	European Union, European Regional Development Fund Greece Alliance of International Science Organizations
Αναγνωριστικό χρηματοδοτικού προγράμματος:	5031682 ANSO-CR-PP-2021-01
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/ijms26083805
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο