Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Metabolic syndrome in patients with schizophrenia: Underlying mechanisms and therapeutic approaches (Review)
Δημιουργός/Συγγραφέας:	Manta, Aspasia Georganta, Anastasia Roumpou, Afroditi [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis [EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A. Rizos, Emmanouil Peppa, Melpomeni
Ημερομηνία:	2025-05
Γλώσσα:	Αγγλικά
ISSN:	1791-2997 1791-3004
DOI:	10.3892/mmr.2025.13479
Άλλο:	40017113
Περίληψη:	Schizophrenia (SCZ) represents a considerable health concern, not only due to its impact on cognitive and psychiatric domains, but also because of its association with metabolic abnormalities. Individuals with SCZ face an increased risk of developing metabolic syndrome (MS), which contributes to the increased cardiovascular burden and reduced life expectancy observed in this population. Metabolic alterations are associated with both the SCZ condition itself and extrinsic factors, particularly the use of antipsychotic medications. Additionally, the link between SCZ and MS seems to be guided by distinct genetic parameters. The present narrative review summarizes the relationship between SCZ and MS and emphasizes the various therapeutic approaches for managing its components in patients with these conditions. Recommended therapeutic approaches include lifestyle modifications as the primary strategy, with a focus on behavioral lifestyle programs, addressing dietary patterns and physical activity. Pharmacological interventions include administering common antidiabetic medications and the selection of less metabolically harmful antipsychotics. Alternative interventions with limited clinical application are also discussed. Ultimately, a personalized therapeutic approach encompassing both the psychological and metabolic aspects is essential for the effective management of MS in patients with SCZ.
Τίτλος πηγής δημοσίευσης:	Molecular medicine reports
Τόμος/Κεφάλαιο:	31
Τεύχος:	5
Θεματική Κατηγορία:	[EL] Νευροεπιστήμη. Βιολογική ψυχιατρική. Νευροψυχιατρική[EN] Neurosciences. Biological psychiatry. Neuropsychiatry [EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	antidiabetic medications antipsychotics diabetes dyslipidemia glucagon‑like peptide‑1 receptor agonists hypertension insulin resistance lifestyle mental illness metabolic syndrome metformin obesity schizophrenia sodium‑glucose transport protein 2 inhibitors
Κάτοχος πνευματικών δικαιωμάτων:	© Manta et al.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article distributed under the terms of Creative Commons Attribution License.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3892/mmr.2025.13479
Σημειώσεις:	Review
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο