Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Rational Design of New Biocompatible Near-Infrared Conjugated Polymer Nanoparticles for Biomedical Applications
Δημιουργός/Συγγραφέας:	Pavlou, Aristea Katsouras, Athanasios Markou, Maria Nega, Alkmini Bellou, Sofia Koralli, Panagiota Schiza, Andriana Chalmpes, Nikolaos [EL] Γρηγορίου, Βασίλης Γ.[EN] Gregoriou, Vasilis G. Dimitrakopoulou-Strauss, Antonia Fotsis, Theodore Avgeropoulos, Apostolos G Siskos, Michael Murphy, Carol [EL] Χώχος, Χρήστος[EN] Chochos, Christos
Ημερομηνία:	2026-02-10
Γλώσσα:	Αγγλικά
ISSN:	0024-9297
DOI:	10.1021/acs.macromol.5c01788
Άλλο:	41768460
Περίληψη:	Conjugated polymer nanoparticles (CPNs) have gained significant attention as promising nanomaterials for cancer theranostics, particularly in fluorescence imaging and therapy, where early detection and image-guided surgery are crucial for effective treatment. Despite growing interest, there remains a notable gap in the literature regarding rational design strategies and clear structure-property relationships for CPN development. Comprehensive design rules that guide the production of CPNs with optimized performance are still lacking, hindering the systematic advancement of this field. Addressing this gap, we synthesized a series of new donor-acceptor (D-A) conjugated polymers (CPs), each incorporating a common acceptor unit paired with three distinct donor groups to assess their impact on optical and biological properties. The resulting nanoparticles exhibited excellent characteristics as fluorescent contrast agents, including enhanced fluorescence intensity in aqueous media along with favorable photostability. Studies using human colorectal carcinoma (HCT-116) and human umbilical vein endothelial cells (HUVEC) confirmed the CPNs' nontoxic nature, strong fluorescence, and biocompatibility. Notably, this study is the first to investigate the cellular uptake mechanism of CPNs in HCT-116 cells, offering valuable insights into their biological interactions. These findings not only demonstrate the potential of these newly developed CPNs for fluorescence imaging of HCT-116 but also underscore the urgent need for rational design frameworks to guide the future development of next-generation CPNs.
Τίτλος πηγής δημοσίευσης:	Macromolecules
Τόμος/Κεφάλαιο:	59
Τεύχος:	3
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Βιοιατρική μηχανική. Ηλεκτρονική. Ενοργάνιση[EN] Biomedical engineering. Electronics. Instrumentation [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Cells Confocal microscopy Endocytosis Fluorescence Nanoparticles
Χρηματοδότης:	Helmholtz Association Hellenic Foundation for Research and Innovation (H.F.R.I.)
Χρηματοδοτικό πρόγραμμα:	Helmholtz European Partnering Program 2nd Call for H.F.R.I. Research Projects to Support Faculty Members & Researchers Basic Research Financing (Horizontal support of all Sciences), National Recovery and Resilience Plan “Greece 2.0” (EU – NextGenerationEU)
Αναγνωριστικό χρηματοδοτικού προγράμματος:	4694 17007
Κάτοχος πνευματικών δικαιωμάτων:	© 2026 The Authors. Published by American Chemical Society.
Όροι και προϋποθέσεις δικαιωμάτων:	This publication is licensed under CC-BY-NC-ND 4.0 .
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1021/acs.macromol.5c01788
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο