Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Synthesis of Comb-like and Coil-Comb Polystyrene-Polyglycidol Copolymers via Click Chemistry: Self-Assembly and Biological Evaluation
Δημιουργός/Συγγραφέας:	Toncheva-Moncheva, Natalia Dimitrov, Erik Delcheva, Niya Momekova, Denitsa Kondeva-Burdina, Magdalena Stefanova, Denitsa Tzankova, Virginia [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Rangelov, Stanislav
Ημερομηνία:	2026-02-19
Γλώσσα:	Αγγλικά
ISSN:	2073-4360
DOI:	10.3390/polym18040517
Άλλο:	41754706
Περίληψη:	Amphiphilic copolymers based on polystyrene and polyglycidol combine the chemical inertness of polystyrene with the biocompatibility of polyglycidol, making them attractive materials for polymeric micelles. While comb-like architectures have been explored to control micellization behavior and biological response, a direct comparison between comb-like and coil-comb topologies in polystyrene-polyglycidol copolymers at identical polyglycidol content remains insufficiently investigated. In this work, amphiphilic comb-like and coil-comb polystyrene-polyglycidol copolymers were synthesized via copper-catalyzed azide-alkyne click chemistry by grafting a monoalkyne-terminated polyglycidol precursor onto azide-functionalized random and block styrene copolymers. The copolymers were characterized by size exclusion chromatography and nuclear magnetic resonance. Polymeric micelles were prepared by nanoprecipitation, and their self-assembly in aqueous solution was investigated by critical micelle concentration determination, dynamic and electrophoretic light scattering, and atomic force microscopy. Both copolymers formed stable aqueous dispersions and exhibited comparable critical micelle concentrations. At identical polyglycidol content, the random copolymer formed a uniform, monomodal micellar population, whereas the block-based coil-comb architecture led to bimodal size distributions, indicating the coexistence of two distinct micellar populations. The investigated systems showed low cytotoxicity and did not induce significant oxidative stress within the studied concentration range. On isolated rat brain sub-cellular fractions (synaptosomes, mitochondria and microsomes), administered alone, the comb-like and coil-comb polystyrene-polyglycidol copolymers did not reveal statistically significant neurotoxic effects. The results demonstrate that macromolecular architecture plays a key role in governing micellar organization and in vitro biological response in polystyrene-polyglycidol copolymers, highlighting their potential as architecture-controlled polymer-based nanocarriers.
Τίτλος πηγής δημοσίευσης:	Polymers
Τόμος/Κεφάλαιο:	18
Τεύχος:	4
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	click chemistry comb-like and coil-comb chain architecture light scattering linear polyglycidol nanocarriers nanoparticles polymer micelles self-assembly
Χρηματοδότης:	European Union
Χρηματοδοτικό πρόγραμμα:	BIORESOURCES BG
Αναγνωριστικό χρηματοδοτικού προγράμματος:	BG16RFPR002-1.014-0001
Κάτοχος πνευματικών δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Όροι και προϋποθέσεις δικαιωμάτων:	© 2026 by the authors. Licensee MDPI, Basel, Switzerland.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/polym18040517
Σημειώσεις:	The support of the Centre of Competence “Sustainable Utilization of Bio-Resources and Waste of Medicinal and Aromatic Plants for Innovative Bioactive Products” (BIORESOURCES BG), project BG16RFPR002-1.014-0001, funded by the Program “Research, Innovation and Digitization for Smart Transformation” 2021–2027, co-funded by the European Union, is greatly acknowledged.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο