Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Cyclo-(His-Phe) Complexes with Copper and Zinc Nanoparticles Have Antimicrobial Properties and Targeted Anticancer Potential Against Osteosarcoma Cells
Δημιουργός/Συγγραφέας:	Apostolidou, Chrysanthi Pinelopi [EL] Χαραλαμπίδης, Γεώργιος[EN] Charalambidis, Georgios Gialouri, Aikaterini Chatzinikolaidou, Maria Mitraki, Anna
Ημερομηνία:	2026-02-11
Γλώσσα:	Αγγλικά
ISSN:	2218-273X
DOI:	10.3390/biom16020284
Άλλο:	41750355
Περίληψη:	Copper and zinc nanoparticles have been suggested as potent anticancer agents, particularly against osteosarcoma, a highly aggressive bone cancer with limited treatment options. In order to avoid systemic toxicity, biomolecular carriers able to chelate metal ions and deliver them in a targeted manner to the vicinity of cancer cells need to be developed. Herein, we have used a histidine-containing, cyclic dipeptide as a carrier able to chelate stabilized copper and zinc nanoparticles. The cyclic peptide cyclo-(histidine-phenylalanine) (cHF) self-assembled into amyloid-type fibrils; morphological and structural characterization following metal addition confirmed the formation of cHF-CuNPs and cHF-ZnNPs. These composite nanoparticles demonstrated bacteriostatic activity against Escherichia coli and Staphylococcus aureus at the in vitro level. We evaluated the optimal concentration of cHF-metalNP complexes with limited cytotoxicity to L929 fibroblasts and high cytotoxic effects against MG-63 osteosarcoma cells. Their cytotoxicity was particularly pronounced at pH 6.4, which emulates the tumor microenvironment. The cHF peptide alone did not demonstrate significant antimicrobial or cytotoxic effects to both cell types, suggesting that it can act as a cytocompatible, pH-responsive carrier of metal ions with targeted dual functionality against both microbial infections and osteosarcoma cancer cells.
Τίτλος πηγής δημοσίευσης:	Biomolecules
Τόμος/Κεφάλαιο:	16
Τεύχος:	2
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Κυτταρολογία[EN] Cytology [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Ανόργανη χημεία[EN] Inorganic chemistry
Λέξεις-Κλειδιά:	amyloid fibrils antimicrobial activity fibroblasts metal nanoparticles osteosarcoma self-assembling peptides
Χρηματοδότης:	Hellenic Foundation for Research and Innovation (HFRI) European Union, European Social Fund-ESF Greece Stavros Niarchos Foundation (SNF)
Χρηματοδοτικό πρόγραμμα:	Operational Programme Human Resources Development, Education and Lifelong Learning IKY Scholarship Program for PhD Candidates in Greek Universities NAIAD
Αναγνωριστικό χρηματοδοτικού προγράμματος:	Fellowship Number: 390 9578
Κάτοχος πνευματικών δικαιωμάτων:	© 2026 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/biom16020284
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο