Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Targeted Delivery of Microneurotrophin BNN27 via Biomaterial Grafts Protects Retinal Ganglion Cells After Optic Nerve Injury
Δημιουργός/Συγγραφέας:	Georgelou, K Saridaki, E A Apostolidou, C P Mallios, X Papagiannaki, A Karali, K [EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodora [EL] Καλογεροπούλου, Θεοδώρα[EN] Calogeropoulou, Theodora Mitraki, A Karagogeos, D Charalampopoulos, I Gravanis, A Savvaki, M Tzeranis, D S
Ημερομηνία:	2026-01
Γλώσσα:	Αγγλικά
ISSN:	1552-4973 1552-4981
DOI:	10.1002/jbmb.70013
Άλλο:	41445417
Περίληψη:	Emerging neurotrophin treatments for optic nerve injury (ONI) aim to prevent the loss of retinal ganglion cells (RGCs) and enhance axonal regeneration. Microneurotrophins (MNTs), small-molecule mimetics of neurotrophins, have shown neuroprotective effects in various animal models of neurodegeneration, yet MNT effects on ONI remain unknown. Here, we study the effects of BNN27, a MNT that mimics NGF, in a mouse model of optic nerve crush (ONC) and compare the targeted administration via biomaterial grafts placed around the ONC lesion against standard eye drop delivery. Compared to eye drop delivery, targeted biomaterial-based BNN27 delivery resulted in more consistent and efficient RGC neuroprotection and reduced microglia-mediated inflammation in the ONC lesion. Our findings demonstrate that targeted delivery of MNTs can alleviate key consequences of ONI and, therefore, be an essential part of effective combinatorial ONI treatments.
Τίτλος πηγής δημοσίευσης:	Journal of biomedical materials research. Part B, Applied biomaterials
Τόμος/Κεφάλαιο:	114
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Οφθαλμολογία[EN] Opthalmology [EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology [EL] Εσωτερική ιατρική[EN] Internal medicine [EL] Μοριακή Βιολογία[EN] Molecular Biology
Λέξεις-Κλειδιά:	biomaterial grafts microneurotrophins neuroprotection optic nerve injury targeted delivery
Χρηματοδότης:	Hellenic Foundation for Research and Innovation (HFRI) General Secretariat for Research and Technology (GSRT)
Αναγνωριστικό χρηματοδοτικού προγράμματος:	1635
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Author(s). Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1002/jbmb.70013
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο