Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Unlocking the potential of micelles: DoE and QbD strategies for formulation development and optimization
Δημιουργός/Συγγραφέας:	Papavasileiou, Eirini-Zoi Rekkas, Dimitrios M. Dallas, Paraskevas P. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Pippa, Natassa
Ημερομηνία:	2026
Γλώσσα:	Αγγλικά
ISSN:	17732247
DOI:	10.1016/j.jddst.2025.107795
Περίληψη:	Micelles have emerged as promising nanocarriers, enhancing drug solubility, stability, and targeted delivery. This review explores the integration of Design of Experiments (DoE) and Quality by Design (QbD) methodologies in optimizing micellar formulations, emphasizing in critical quality attributes (CQAs) and process parameters (CPPs). Nanoscale polymeric, mixed, and stimuli-responsive micelles are mainly evaluated, with Factorial, Central Composite and Box-Behnken designs enabling systematic optimization of particle size, encapsulation efficiency, zeta potential, polydispersity index and release kinetics. Case studies highlight therapeutic advancements in cancer, ocular delivery, and neurological disorders, demonstrating improved bioavailability and reduced systemic toxicity. Additionally, DoE-driven approaches enhance formulation robustness and reproducibility, aligning with regulatory standards. However, large-scale production, long-term stability, and physiological variability challenges persist. This review underscores the transformative role of systematic methodologies in advancing micellar nanomedicines while emphasizing the need for standardized protocols to address manufacturing and regulatory barriers through analysing multiple recent research-oriented case studies.
Τίτλος πηγής δημοσίευσης:	Journal of Drug Delivery Science and Technology
Τόμος/Κεφάλαιο:	115
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φαρμακευτική τεχνολογία[EN] Pharmaceutical technology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Micelles Formulation and development studies Physicochemical characteristics Optimization Factors Responses
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Authors. Published by Elsevier B.V.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.jddst.2025.107795
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο