Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Evaluating the prognostic efficacy of biomarkers in pancreatic cyst fluid
Δημιουργός/Συγγραφέας:	Varvarelis, Orfeas P Voulgaris, Theodoros A Skreka, Androniki-Maria Themelidi, Vasiliki [EL] Βουτσινά, Αλεξάνδρα[EN] Voutsina, Alexandra Vezakis, Antonios
Ημερομηνία:	2025-10-16
Γλώσσα:	Αγγλικά
ISSN:	1948-5190
DOI:	10.4253/wjge.v17.i10.109037
Άλλο:	41181530
Περίληψη:	Evaluating the prognostic significance of biomarkers in pancreatic cyst fluid, accessed through endoscopic ultrasound-guided fine-needle aspiration, is essential for improving the clinical management of pancreatic cysts. This review synthesizes the evidence from studies published on the field in the last years, focusing on the accuracy and clinical utility of biomarkers such as carcinoembryonic antigen, intracystic glucose, and novel genetic markers including DNA mutation analysis. Our findings indicate that elevated carcinoembryonic antigen levels and decreased intra-cystic glucose levels are strongly associated with mucinous cysts which carry a higher malignancy risk, while DNA mutation analysis has shown increased predictive accuracy for identifying malignant transformations. Integrating these biomarkers with imaging techniques enhances risk stratification and can significantly influence therapeutic decisions. The review highlights the need for standardization of biomarker assays and further validation of biomarker panels to refine their prognostic value in clinical settings, ultimately aiding in the tailored management of patients with pancreatic cysts.
Τίτλος πηγής δημοσίευσης:	World journal of gastrointestinal endoscopy
Τόμος/Κεφάλαιο:	17
Τεύχος:	10
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Παθολογία[EN] Pathology [EL] Μοριακή Βιολογία[EN] Molecular Biology
Λέξεις-Κλειδιά:	Cyst fluid biomarkers Endoscopic ultrasound Moucinous cysts Pancreatic cysts Prognostic evaluation
Κάτοχος πνευματικών δικαιωμάτων:	©The Author(s) 2025
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://dx.doi.org/10.4253/wjge.v17.i10.109037
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο