Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Polyphosphocholination of liposomic vehicles extends blood circulation, enhances cellular uptake, and lowers immunogenicity relative to PEGylation
Δημιουργός/Συγγραφέας:	Kluzek, Monika Hamad, Maryana Lin, Weifeng [EL] Μήτσου, Ευγενία[EN] Mitsou, Evgenia Porat, Ziv Kuznetsov, Yuri Oppenheimer-Shaanan, Yaara Klein, Jacob
Ημερομηνία:	2025-10-10
Γλώσσα:	Αγγλικά
ISSN:	01683659
DOI:	10.1016/j.jconrel.2025.114306
Άλλο:	41077146
Περίληψη:	Intravenous liposomal drug delivery holds great promise for pharmaceutical efficacy, but faces challenges such as rapid clearance and immune system degradation. PEG-based liposome surface functionalization (PEGylation), currently the gold-standard and most widely-used approach to address these issues, is prone to reduced cellular uptake and accelerated bloodstream clearance (ABC) effect upon repeated administration due to immune activation. We demonstrate a novel liposome surface functionalization using poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) that significantly overcomes these limitations while maintaining comparable colloidal stability. Such polyphosphocholinated liposomes exhibit tunable cellular uptake, and prolonged blood circulation times, both modulated by polymer length, alongside reduced immunogenicity (lower IgM antibody elicitation) and a diminished ABC effect compared to PEG-liposomes. These polymer-length-dependent properties offer flexibility in optimizing drug delivery systems, positioning pMPCylated liposomes as a compelling alternative to PEGylated formulations with clear advantages for liposomal drug delivery therapeutics.
Τίτλος πηγής δημοσίευσης:	Journal of controlled release : official journal of the Controlled Release Society
Τόμος/Κεφάλαιο:	388
Τεύχος:	Pt 1
Θεματική Κατηγορία:	[EL] Βιοτεχνολογία[EN] Biotechnology [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Ανοσολογία[EN] Immunology
Λέξεις-Κλειδιά:	Blood circulation Immune response Liposomic delivery vehicles PEGylated liposomes Polyphosphocholinated liposomes
Χρηματοδότης:	European Research Council Israel Ministry of Science and Industry Weizmann Institute of Science Israel Science Foundation Narodowe Centrum Nauki Egg Farmers of Canada
Χρηματοδοτικό πρόγραμμα:	Horizon 2020 Framework Programme NanodeliveryEnhance project NCN OPUS26
Αναγνωριστικό χρηματοδοτικού προγράμματος:	713272 ISF-NSFC 2577/17 No. 743016 101082135 2023/51/B/NZ7/01177 US10730976B2
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Authors. Published by Elsevier B.V.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.jconrel.2025.114306
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο