Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Xanthan-based nanocomplexes: modulating colloidal properties, model compound encapsulation and mucoadhesion via diethylaminoethyl dextran
Δημιουργός/Συγγραφέας:	Pispas, Ioannis Pavlova, Ewa Slouf, Miroslav [EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis
Ημερομηνία:	2025-09-18
Γλώσσα:	Αγγλικά
ISSN:	01418130
DOI:	10.1016/j.ijbiomac.2025.147766
Άλλο:	40975335
Περίληψη:	Xanthan gum (XG) and diethylaminoethyl dextran (DD) electrostatic nanocomplexes (NCs) are prepared at the native (NCs) and thermally denatured state of XG (den-NCs). Dynamic and static light scattering (DLS and SLS) and transmission electron microscopy (TEM) reveal well-defined, spherical NCs with mean hydrodynamic and gyroscopic radii of 100-200 nm at charge ratios (ratio of anionic XG to cationic DD monomers) between 0.4 and 5. Their size increases at CR > 1 possibly due to XG-XG double helix formation. Surface potential shifts from positive to negative between CR 1 and 1.25, suggesting stoichiometric neutralization. NCs remain stable for over one month without significant aggregation. Fluorescence measurements with pyrene and 8-Anilino-1-naphthalenesulfonate (ANS) indicate the presence of hydrophobic domains inside the NCs attributed to DD's ethyl groups, which renders them suitable for the encapsulation of hydrophobic compounds. High loading efficiency (∼48 %) and loading capacity (∼19 %) for β-carotene (β-C) is found for native NCs at CR 0.4 and 2.5, whereas den-NCs show significantly lower encapsulation. NCs interact with porcine gastric mucin (PGM) in PGM solutions as it is confirmed by NC-PGM aggregation. Mucoadhesion is also examined with mucus-mimicking PGM-immobilized alginate beads. Positively charged NCs exhibit enhanced mucoadhesion relative to negatively charged ones. Overall, XG/DD NCs display tunable properties promising for drug delivery applications with notable stability, encapsulation and mucoadhesive capabilities.
Τίτλος πηγής δημοσίευσης:	International journal of biological macromolecules
Τόμος/Κεφάλαιο:	329
Τεύχος:	Pt 1
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Βιοχημεία[EN] Biochemistry [EL] Φαρμακευτική τεχνολογία[EN] Pharmaceutical technology
Λέξεις-Κλειδιά:	Mucus analogs Mucus mimics Polysaccharide nanogels Polysaccharide nanoparticles β-Carotene
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Authors. Published by Elsevier B.V.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.ijbiomac.2025.147766
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο