Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Causal Inference Approaches Reveal Associations Between LDL Oxidation, NO Metabolism, Telomere Length and DNA Integrity Within the MARK-AGE Study
Δημιουργός/Συγγραφέας:	Valeanu, Andrei Margina, Denisa Moreno-Villanueva, María Blasco, María Sikora, Ewa Mosieniak, Grazyna Capri, Miriam Breusing, Nicolle Bernhardt, Jürgen Schön, Christiane Toussaint, Olivier Debacq-Chainiaux, Florence Grubeck-Loebenstein, Beatrix Weinberger, Birgit Fiegl, Simone [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Hervonen, Antti Slagboom, Eline P de Craen, Anton Dollé, Martijn E T Jansen, Eugène H J M Mocchegiani, Eugenio Giacconi, Robertina Piacenza, Francesco Malavolta, Marco Weber, Daniela Stuetz, Wolfgang Grune, Tilman Franceschi, Claudio Bürkle, Alexander Gradinaru, Daniela
Ημερομηνία:	2025-07-30
Γλώσσα:	Αγγλικά
ISSN:	2076-3921
DOI:	10.3390/antiox14080933
Άλλο:	40867830
Περίληψη:	Genomic instability markers are important hallmarks of aging, as previously evidenced within the European study of biomarkers of human aging, MARK-AGE; however, establishing the specific metabolic determinants of vascular aging is challenging. The objective of the present study was to evaluate the impact of the susceptibility to oxidation of serum LDL particles (LDLox) and the plasma metabolization products of nitric oxide (NOx) on relevant genomic instability markers. The analysis was performed on a MARK-AGE cohort of 1326 subjects (635 men and 691 women, 35-75 years old) randomly recruited from the general population. The Inverse Probability of Treatment Weighting causal inference algorithm was implemented in order to assess the potential causal relationship between the LDLox and NOx octile-based thresholds and three genomic instability markers measured in mononuclear leukocytes: the percentage of telomeres shorter than 3 kb, the initial DNA integrity, and the DNA damage after irradiation with 3.8 Gy. The results showed statistically significant telomere shortening for LDLox, while NOx yielded a significant impact on DNA integrity. Overall, the effect on the genomic instability markers was higher than for the confirmed vascular aging determinants, such as low HDL cholesterol levels, indicating a meaningful impact even for small changes in LDLox and NOx values.
Τίτλος πηγής δημοσίευσης:	Antioxidants (Basel, Switzerland)
Τόμος/Κεφάλαιο:	14
Τεύχος:	8
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Γηριατρική[EN] Geriatrics [EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology [EL] Παθολογία[EN] Pathology
Λέξεις-Κλειδιά:	LDL oxidation MARK-AGE causal analysis genomic instability markers nitric oxide vascular aging
Χρηματοδότης:	European Commission
Χρηματοδοτικό πρόγραμμα:	MARK-AGE
Αναγνωριστικό χρηματοδοτικού προγράμματος:	200880
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/antiox14080933
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο