Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases
Δημιουργός/Συγγραφέας:	Zota, Ioanna [EL] Καλογεροπούλου, Θεοδώρα[EN] Calogeropoulou, Theodora Chanoumidou, Konstantina Charalampopoulos, Ioannis Gravanis, Achille
Ημερομηνία:	2025-07-23
Γλώσσα:	Αγγλικά
ISSN:	0007-1188 1476-5381
DOI:	10.1111/bph.70143
Άλλο:	40702789
Περίληψη:	Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic therapies. Several studies highlight the role of neurotrophic factors (NTFs) as potential neuroprotective, regenerative therapies for these disorders. Although NTFs hold protective and regenerative potential for chronic neuroinflammatory and neurodegenerative conditions, major hurdles impair their clinical use, such as optimising the dosage of NTFs, minimising the invasiveness of delivery methods, overcoming blood-brain-barrier (BBB) impermeability and managing side effects. In the last two decades our group have synthesised and screened a large chemical library of steroidal analogues of dehydroepiandrosterone (DHEA), an endogenous steroid hormone, for their ability to mimic neurotrophin neuroprotective and neurogenic actions. Interestingly, DHEA was shown to interact with all neurotrophin receptors, acting most probably as an ancestral neurotrophin early in evolution. However, its chronic pharmacological use is questioned by its action as a major precursor of steroidogenesis. This review highlights the findings of numerous preclinical studies on these synthetic, non-toxic, BBB permeable DHEA derivatives, named microneurotrophins (MNTs), deprived of endocrine actions, activators of specific neurotrophin receptors. The multimodal actions of MNTs against neuronal death and activation of microglia, in addition to their beneficial effects in synaptogenesis and neurogenesis, place them as interesting lead molecules in the armamentarium of therapeutics for neurodegeneration.
Τίτλος πηγής δημοσίευσης:	British journal of pharmacology
Θεματική Κατηγορία:	[EL] Νευροεπιστήμη. Βιολογική ψυχιατρική. Νευροψυχιατρική[EN] Neurosciences. Biological psychiatry. Neuropsychiatry [EL] Μοριακή Βιολογία[EN] Molecular Biology [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology
Λέξεις-Κλειδιά:	Alzheimer's disease BDNF NGF Parkinson's disease Trk receptors amyotrophic lateral sclerosis diabetic retinopathy microneurotrophins multiple sclerosis p75 neurotrophin receptor
Χρηματοδότης:	European Regional Development Fund of the European Union and Greek
Χρηματοδοτικό πρόγραμμα:	FP7 Health
Αναγνωριστικό χρηματοδοτικού προγράμματος:	Dinnesmin
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Author(s). British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1111/bph.70143
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο