Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Elucidating DNA Damage-Dependent Immune System Activation
Δημιουργός/Συγγραφέας:	Deligianni, Elisavet Papanikolaou, Christina Terpos, Evangelos [EL] Σουλιώτης, Βασίλης Λ.[EN] Souliotis, Vassilis L.
Ημερομηνία:	2025-06-18
Γλώσσα:	Αγγλικά
ISSN:	1422-0067
DOI:	10.3390/ijms26125849
Άλλο:	40565309
Περίληψη:	The DNA-damage response (DDR) network and the immune system are significant mechanisms linked to the normal functioning of living organisms. Extensive observations suggest that agents that damage the DNA can boost immunity in various ways, some of which may be useful for immunotherapeutic applications. Indeed, the immune system can be activated by the DDR network through a number of different mechanisms, such as via (a) an increase in the tumor neoantigen burden, (b) the induction of the stimulator of interferon genes pathway, (c) the triggering of immunogenic cell death, (d) an increase in antigen presentation as a result of the augmented expression of the major histocompatibility complex type I molecule, (e) modification of the cytokine milieu in the tumor microenvironment, and (f) altered expression of the programmed cell death ligand-1. Together, the DDR network may improve the effect of immunostimulatory anticancer agents and provide a basis for devising more efficient treatment strategies, such as combinatorial therapies of DDR targeting drugs and immunomodulators. Here, the molecular mechanisms underlying the immune system's activation by DDR are summarized, along with some of their possible uses in cancer treatment.
Τίτλος πηγής δημοσίευσης:	International journal of molecular sciences
Τόμος/Κεφάλαιο:	26
Τεύχος:	12
Θεματική Κατηγορία:	[EL] Ανοσολογία[EN] Immunology [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Μοριακή Βιολογία[EN] Molecular Biology [EL] Βιοχημεία[EN] Biochemistry [EL] Κυτταρολογία[EN] Cytology
Λέξεις-Κλειδιά:	DNA-damage response (DDR) immune checkpoint inhibitor immune system immunogenic cell death (ICD) major histocompatibility complex type I (MHC-I) programmed cell death ligand-1 (PD-L1) stimulator of interferon genes (STING) tumor mutational burden (TMB) tumor neoantigen burden (TNB)
Χρηματοδότης:	European Union
Αναγνωριστικό χρηματοδοτικού προγράμματος:	101097094-ELMUMY
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/ijms26125849
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο