Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Next generation risk assessment and new approach methodologies for safe and sustainable by design chemicals and materials: Perspectives and challenges for occupational health
Δημιουργός/Συγγραφέας:	Leso, Veruscka Nowack, Bernd Karakoltzidis, Achilleas Nikiforou, Fotini Karakitsios, Spyros [EL] Σαρηγιάννης, Δημοσθένης[EN] Sarigiannis, Dimosthenis Iavicoli, Ivo
Ημερομηνία:	2025-06-07
Γλώσσα:	Αγγλικά
ISSN:	0300483X
DOI:	10.1016/j.tox.2025.154211
Άλλο:	40490209
Περίληψη:	Europe is facing increasingly challenging threats to health and well-being, including chemical pollution, climate change, and biodiversity loss. To counter such threats, the European Union has developed a series of policy strategies, including the Chemicals Strategy for Sustainability and the Zero Pollution Action Plan that pointed out the need for safe-and-sustainable-by-design (SSbD) chemicals/materials. The SSbD and the "zero pollution" ambition will inevitably lead to a transformation of the conditions of exposure to chemicals both in general living environments and workplaces with the consequent need to adequately anticipate and manage the chemical risk, starting from the assessment of the hazard and risk characterization. Among those, next generation risk assessment (NGRA) is defined as a human-relevant, exposure-led, hypothesis driven risk assessment approach, designed to prevent harm. To date, application of NGRA has been restricted to assessing the use of cosmetics, and it has not been implemented in occupational risk assessment. Occupational safety assessment represents an area that would benefit from increasing application of NGRA to safety decision making. Additionally, the application of new approach methodologies (NAMs) can support the generation of data useful to implement the operationalization of the SSbD framework, favorably impacting the adoption of suitable management strategies. In turn, the historical occupational preventive and protective approach to the health and safety of workers may provide support to adequately implement NGRA in the occupational context. Therefore, this work aims to provide an overview on the principal available NAMs and their possible implications for occupational chemical risk assessment and management.
Τίτλος πηγής δημοσίευσης:	Toxicology
Τόμος/Κεφάλαιο:	517
Θεματική Κατηγορία:	[EL] Τοξικολογία[EN] Toxicology. Poisons [EL] Χημεία[EN] Chemistry [EL] Δημόσια υγεία. Υγιεινή. Προληπτική ιατρική[EN] Public health. Hygiene. Preventive medicine
Λέξεις-Κλειδιά:	Adverse outcome pathways Chemicals Governance Occupational medicine Risk management Safe and sustainability
Χρηματοδότης:	European Union
EU Grant:	Horizon Europe (HORIZON)
EU Grant identifier:	101057014
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Authors. Published by Elsevier B.V. All rights reserved.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.tox.2025.154211
Εμφανίζεται στις συλλογές:	Άλλες δράσεις