Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Advancing translational exposomics: bridging genome, exposome and personalized medicine
Δημιουργός/Συγγραφέας:	[EL] Σαρηγιάννης, Δημοσθένης[EN] Sarigiannis, Dimosthenis Karakitsios, Spyros Anesti, Ourania Stem, Arthur Valvi, Damaskini Sumner, Susan C J Chatzi, Leda Snyder, Michael P Thompson, David C Vasiliou, Vasilis
Ημερομηνία:	2025-04-30
Γλώσσα:	Αγγλικά
ISSN:	1479-7364
DOI:	10.1186/s40246-025-00761-6
Άλλο:	40307849
Περίληψη:	Understanding the interplay between genetic predisposition and environmental and lifestyle exposures is essential for advancing precision medicine and public health. The exposome, defined as the sum of all environmental exposures an individual encounters throughout their lifetime, complements genomic data by elucidating how external and internal exposure factors influence health outcomes. This treatise highlights the emerging discipline of translational exposomics that integrates exposomics and genomics, offering a comprehensive approach to decipher the complex relationships between environmental and lifestyle exposures, genetic variability, and disease phenotypes. We highlight cutting-edge methodologies, including multi-omics technologies, exposome-wide association studies (EWAS), physiology-based biokinetic modeling, and advanced bioinformatics approaches. These tools enable precise characterization of both the external and the internal exposome, facilitating the identification of biomarkers, exposure-response relationships, and disease prediction and mechanisms. We also consider the importance of addressing socio-economic, demographic, and gender disparities in environmental health research. We emphasize how exposome data can contextualize genomic variation and enhance causal inference, especially in studies of vulnerable populations and complex diseases. By showcasing concrete examples and proposing integrative platforms for translational exposomics, this work underscores the critical need to bridge genomics and exposomics to enable precision prevention, risk stratification, and public health decision-making. This integrative approach offers a new paradigm for understanding health and disease beyond genetics alone.
Τίτλος πηγής δημοσίευσης:	Human genomics
Τόμος/Κεφάλαιο:	19
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology [EL] Γενετική[EN] Genetics [EL] Βιοπληροφορική[EN] Bioinformatics [EL] Περιβαλλοντική υγεία[EN] Environmental health
Λέξεις-Κλειδιά:	humans Genome-Wide Association Study Genetic Predisposition to Disease precision medicine exposome genomics environmental exposure Translational Research, Biomedical genome, human
Χρηματοδότης:	European Commission U.S. National Institutes of Health Leona M. and Harry B. Helmsley Charitable Trust
EU Grant:	NEUROSOME URBANOME ENVESOME
EU Grant identifier:	766251, DS 945391, DS 101157269, DS AA022057 (VV) ES033815 (VV) CA268153 (SCJS) ES03085 (SCJS) ES030364 (LVC) ES036253 (LVC) HG013288 (LVC) ES029944 (LVC) ES007048 (LVC) ES033688 (DV) ES035148 ES035773 ES023515 (DV) G-2004-03820, MPS
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Author(s)
Όροι και προϋποθέσεις δικαιωμάτων:	Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1186/s40246-025-00761-6
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