Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps
Δημιουργός/Συγγραφέας:	Jaylet, Thomas Coustillet, Thibaut Smith, Nicola M Viviani, Barbara Lindeman, Birgitte Vergauwen, Lucia Myhre, Oddvar Yarar, Nurettin Gostner, Johanna M Monfort-Lanzas, Pablo Jornod, Florence Holbech, Henrik Coumoul, Xavier [EL] Σαρηγιάννης, Δημοσθένης[EN] Sarigiannis, Dimosthenis Antczak, Philipp Bal-Price, Anna Fritsche, Ellen Kuchovska, Eliska Stratidakis, Antonios K Barouki, Robert Kim, Min Ji Taboureau, Olivier Wojewodzic, Marcin W Knapen, Dries Audouze, Karine
Ημερομηνία:	2024
Γλώσσα:	Αγγλικά
ISSN:	2673-3080
DOI:	10.3389/ftox.2024.1285768
Άλλο:	38523647
Περίληψη:	Introduction: The Adverse Outcome Pathway (AOP) concept facilitates rapid hazard assessment for human health risks. AOPs are constantly evolving, their number is growing, and they are referenced in the AOP-Wiki database, which is supported by the OECD. Here, we present a study that aims at identifying well-defined biological areas, as well as gaps within the AOP-Wiki for future research needs. It does not intend to provide a systematic and comprehensive summary of the available literature on AOPs but summarizes and maps biological knowledge and diseases represented by the already developed AOPs (with OECD endorsed status or under validation). Methods: Knowledge from the AOP-Wiki database were extracted and prepared for analysis using a multi-step procedure. An automatic mapping of the existing information on AOPs (i.e., genes/proteins and diseases) was performed using bioinformatics tools (i.e., overrepresentation analysis using Gene Ontology and DisGeNET), allowing both the classification of AOPs and the development of AOP networks (AOPN). Results: AOPs related to diseases of the genitourinary system, neoplasms and developmental anomalies are the most frequently investigated on the AOP-Wiki. An evaluation of the three priority cases (i.e., immunotoxicity and non-genotoxic carcinogenesis, endocrine and metabolic disruption, and developmental and adult neurotoxicity) of the EU-funded PARC project (Partnership for the Risk Assessment of Chemicals) are presented. These were used to highlight under- and over-represented adverse outcomes and to identify and prioritize gaps for further research. Discussion: These results contribute to a more comprehensive understanding of the adverse effects associated with the molecular events in AOPs, and aid in refining risk assessment for stressors and mitigation strategies. Moreover, the FAIRness (i.e., data which meets principles of findability, accessibility, interoperability, and reusability (FAIR)) of the AOPs appears to be an important consideration for further development.
Τίτλος πηγής δημοσίευσης:	Frontiers in toxicology
Τόμος/Κεφάλαιο:	6
Θεματική Κατηγορία:	[EL] Βιοπληροφορική[EN] Bioinformatics [EL] Τοξικολογία[EN] Toxicology. Poisons [EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology [EL] Μοριακή Βιολογία[EN] Molecular Biology
Λέξεις-Κλειδιά:	AOP network PARC adverse outcome pathway diseases immunotoxicity neurotoxicity nongenotoxic carcinogenesis
Χρηματοδότης:	European Union
EU Grant:	Horizon 2020 Research and Innovation Programme PARC project OBERON ONTOX RadoNorm
EU Grant identifier:	101057014 825712 963845 900009
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 Jaylet, Coustillet, Smith, Viviani, Lindeman, Vergauwen, Myhre, Yarar, Gostner, Monfort-Lanzas, Jornod, Holbech, Coumoul, Sarigiannis, Antczak, Bal-Price, Fritsche, Kuchovska, Stratidakis, Barouki, Kim, Taboureau, Wojewodzic, Knapen and Audouze
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3389/ftox.2024.1285768
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