Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Viscoelastic Response of Double Hydrophilic Block Copolymers for Drug Delivery Applications
Δημιουργός/Συγγραφέας:	Pipertzis, Achilleas Chroni, Angeliki [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Swenson, Jan
Ημερομηνία:	2025-07-02
Γλώσσα:	Αγγλικά
ISSN:	2073-4360
DOI:	10.3390/polym17131857
Άλλο:	40647867
Περίληψη:	This study investigates the mechanical properties of double hydrophilic block copolymers (DHBCs) based on poly[oligo(ethylene glycol) methacrylate] (POEGMA) and poly(vinyl benzyl trimethylammonium chloride) (PVBTMAC) blocks by employing small amplitude oscillatory shear (SAOS) rheological measurements. We report that the mechanical properties of DHBCs are governed by the interfacial glass transition temperature (Tginter), verifying the disordered state of these copolymers. An increase in zero shear viscosity can be observed by increasing the VBTMAC content, yielding a transition from liquid-like to gel-like and finally to an elastic-like response for the PVBTMAC homopolymer. By changing the block arrangement along the backbone from statistical to sequential, a distinct change in the viscoelastic response is obvious, indicating the presence/absence of bulk-like regions. The tunable viscosity values and shear-thinning behavior achieved through alteration of the copolymer composition and block arrangement along the backbone render the studied DHBCs promising candidates for drug delivery applications. In the second part, the rheological data are analyzed within the framework of the classical free volume theories of glass formation. Specifically, the copolymers exhibit reduced fractional free volume and similar fragility values compared to the PVBTMAC homopolymer. On the contrary, the activation energy increases by increasing the VBTMAC content, reflecting the required higher energy for the relaxation of the glassy VBTMAC segments. Overall, this study provides information about the viscoelastic properties of DHBCs with densely grafted macromolecular architecture and shows how the mechanical and dynamical properties can be tailored for different drug delivery applications by simply altering the ratio between the two homopolymers.
Τίτλος πηγής δημοσίευσης:	Polymers
Τόμος/Κεφάλαιο:	17
Τεύχος:	13
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	densely grafted architecture double hydrophilic block copolymer rheology viscoelastic response
Χρηματοδότης:	Chalmers University of Technology
EU Grant identifier:	C 2024-0296
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/polym17131857
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο