Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	FmocFF Peptide Hydrogel Is a Promising Matrix for Encapsulation and Controlled Release of the Anticancer Peptide Drug Bortezomib
Δημιουργός/Συγγραφέας:	Divanach, Peter Noti, Antzela Vouvopoulos, Panagiotis Athanasiou, Thanasis Kountourakis, Nikos Harmandaris, Vagelis [EL] Ρισσάνου, Αναστασία[EN] Rissanou, Anastassia Mitraki, Anna
Ημερομηνία:	2025-06-08
Γλώσσα:	Αγγλικά
ISSN:	2218-273X
DOI:	10.3390/biom15060839
Άλλο:	40563480
Περίληψη:	One major public health issue is cancer chemotherapy; despite constant progress in the area, administration of anticancer drugs to patients is often associated with serious side effects. It is therefore imperative to develop vehicles for encapsulation and controlled delivery of such drugs. Anticancer drugs include small peptide drugs, such as Bortezomib (BTZ). Self-assembling peptides have been recently reported as promising drug delivery agents. The research reported here proposes the encapsulation of BTZ into peptide hydrogels formed by the self-assembling FmocFF dipeptide as delivery vehicle. We selected FmocFF as an encapsulation vehicle based on our previous simulation study on the complexation propensity of Bortezomib (BTZ) with various peptide gelators. Herein we undertook additional computational studies that highlight the benefits of FmocFF as a potential effective nanocarrier for BTZ combined with experiments of encapsulation and evaluation of BTZ release. Based on these computational and experimental results, we propose the Fmoc-FF dipeptide hydrogel as a promising matrix for the controlled delivery of BTZ.
Τίτλος πηγής δημοσίευσης:	Biomolecules
Τόμος/Κεφάλαιο:	15
Τεύχος:	6
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Βιοτεχνολογία[EN] Biotechnology [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens)
Λέξεις-Κλειδιά:	FmocFF Bortezomib controlled release molecular dynamics peptide hydrogels self-assembly
Χρηματοδότης:	European Regional Development Fund Stavros Niarchos Foundation (SNF) Hellenic Foundation for Research and Innovation (H.F.R.I.)
EU Grant:	Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE Science and Society Action—Always Strive for Excellence—Theodore Papazoglou
EU Grant identifier:	T1EDK—01504 9578
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/biom15060839
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο