Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	pH-Responsive Hydrogels: Recent Advances in Pharmaceutical Applications
Δημιουργός/Συγγραφέας:	Patroklou, Georgia Triantafyllopoulou, Efstathia Goula, Paraskevi-Evelina Karali, Vasiliki Chountoulesi, Maria Valsami, Georgia [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Pippa, Natassa
Ημερομηνία:	2025-05-23
Γλώσσα:	Αγγλικά
ISSN:	2073-4360
DOI:	10.3390/polym17111451
Άλλο:	40508694
Περίληψη:	Hydrogels are three-dimensional polymeric systems, being able to accommodate different categories of bioactive agents and act as promising drug delivery systems in many different biomedical applications. Due to their extended 3D network, hydrogels exhibit many advantages, such as extensive loading capacity and controlled drug release profiles, combined with characteristics such as biocompatibility and biodegradability, due to their constructive polymeric biomaterials. Moreover, hydrogels are capable of being administered via different routes of administration, including systemic and topical ones, due to their tunable characteristics. Stimuli-responsive hydrogels are characterized as smart biomaterials, while environmental stimuli, such as pH, can be employed to trigger on-demand drug release from the hydrogels via the provocation of conformational changes. In the present study, an emphasis on the pH-responsive hydrogels is taking place through various literature cases in drug delivery, wound healing, and some alternative applications, including implantation, oral administration, etc., wherein many different polymeric derivatives have been utilized. Moreover, the role of each used polymer or polymeric combination with other functional biomaterials, their mode of structure formation (for example, crosslinking), and their content release mechanism are highlighted, as well as the therapeutic effect of the hydrogels on different pathological conditions, as promising candidates for pharmaceutical applications.
Τίτλος πηγής δημοσίευσης:	Polymers
Τόμος/Κεφάλαιο:	17
Τεύχος:	11
Θεματική Κατηγορία:	[EL] Φαρμακευτική τεχνολογία[EN] Pharmaceutical technology [EL] Βιοιατρική μηχανική. Ηλεκτρονική. Ενοργάνιση[EN] Biomedical engineering. Electronics. Instrumentation
Λέξεις-Κλειδιά:	anticancer therapy chitosan controlled release drug delivery hydrogels pH-responsive poly(acrylic acid) polymers wound healing
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 by the authors.
Όροι και προϋποθέσεις δικαιωμάτων:	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/polym17111451
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο