Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	P(LMA-co-tBMA-co-MAA) Copolymers Bearing Amphiphilic and Polyelectrolyte Characteristics: Synthetic Aspects and Properties in Aqueous Solutions
Δημιουργός/Συγγραφέας:	Balafouti, Anastasia Pispas, Stergios
Ημερομηνία:	2025-05-26
Γλώσσα:	Αγγλικά
ISSN:	2073-4360
DOI:	10.3390/polym17111473
Άλλο:	40508715
Περίληψη:	In this study, we explore the design of novel random poly(lauryl methacrylate-co-tert-butyl methacrylate-co-methacrylic acid), P(LMA-co-tBMA-co-MAA) copolymers via the RAFT copolymerization of LMA and tBMA followed by the selective hydrolysis of tBMA segments. For the molecular characterization of the novel copolymer, a series of physicochemical techniques were implemented, including size exclusion chromatography (SEC), proton nuclear magnetic resonance (1H-NMR) and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy. Our experimental results confirmed the successful synthesis of the targeted copolymers. The compositions were in accordance with the targeted differing fraction of hydrophobic tBMA/LMA elements, and hydrolysis resulted in at least 64% conversion to hydrophilic MAA units. The copolymers, bearing both an amphiphilic character and polyelectrolyte properties while being composed of randomly distributed monomeric segments of biocompatible materials, were subsequently investigated in terms of their self-assembly behavior in aqueous solutions. Dynamic light scattering and fluorescence spectroscopy experiments demonstrated the formation of self-assembled nanoaggregates (average hydrodynamic radii, Rh < 100 nm) that formed spontaneously, having low critical aggregation concentration (CAC) values (below 3.5 × 10-6 g/mL), and highlighted the feasibility of using these copolymer systems as nanocarriers for biomedical applications.
Τίτλος πηγής δημοσίευσης:	Polymers
Τόμος/Κεφάλαιο:	17
Τεύχος:	11
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	RAFT amphiphilic random copolymers hydrolysis nanoaggregates pH responsive polyelectrolytes post-polymerization modification self-assembly
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/polym17111473
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο