Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Hydroxypropyl methacrylate stars as versatile carriers of therapeutic agents
Δημιουργός/Συγγραφέας:	Sentoukas, Theodore Forys, Alexander Otulakowski, Łukasz Marcinkowski, Andrzej [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Trzebicka, Barbara
Ημερομηνία:	2024
Γλώσσα:	Αγγλικά
ISSN:	0021-8995 1097-4628
DOI:	10.1002/app.55305
Περίληψη:	Three star-like carriers with poly(hydroxy propyl methacrylate) (PHPMA) cores and poly(oligoethylene glycol methacrylate) (POEGMA) arms as nanocarriers were utilized for the encapsulation of rhodamine B, resveratrol, and curcumin. These drugs differ in hydrophobicity and therapeutic effects. The carriers had high encapsulation and loading efficiency (>95% and 10 wt%, respectively) and formed hydrogen bonds with the drugs. They were spherical in phosphate buffer saline and formed aggregates of various sizes (11–116 nm) depending on the star composition and the drug type. The carriers were stable for 2 months, but released different amounts of drugs afterwards, except for curcumin, which stayed entrapped. The curcumin-loaded carriers also generated reactive oxygen species. These findings demonstrate the versatility of PHPMA/POEGMA stars as nanocarriers for diverse applications in nanomedicine.
Τίτλος πηγής δημοσίευσης:	Journal of Applied Polymer Science
Τόμος/Κεφάλαιο:	141
Τεύχος:	18
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	copolymers drug delivery systems morphology self-assembly supramolecular structures
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 Wiley Periodicals LLC.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1002/app.55305
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο