Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Fabricating hybrid DSPC:DOPC:P(OEGMA-co-LMA) structures: Self-assembly as the milestone of their performance
Δημιουργός/Συγγραφέας:	Triantafyllopoulou, Efstathia Selianitis, Dimitrios Balafouti, Anastasia Lagopati, Nefeli Gazouli, Maria Valsami, Georgia [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Pippa, Natassa
Ημερομηνία:	2024
Γλώσσα:	Αγγλικά
ISSN:	09277757
DOI:	10.1016/j.colsurfa.2023.133015
Περίληψη:	Lipid/polymer nanoparticles are among the most promising hybrid nanoplatforms for pharmaceutical applications, and their many advantages are well established. Despite the efforts, the design parameters that influence their performance have not been deciphered in total yet. In this study, thermodynamic evaluation of lipid and lipid/copolymer bilayers was conducted via differential scanning calorimetry (DSC). Based on their biophysical behavior and by modulating different design parameters for each system, selected lipid/copolymer nanostructures were prepared by the thin film hydration method. The biomaterials of choice were 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and a linear statistical (random) copolymer comprised of oligo (ethylene glycol) methyl ether methacrylate (OEGMA) and lauryl methacrylate (LMA). Their features were examined by light scattering techniques, fluorescence spectroscopy, and MTS assay. For the first time DSPC:DOPC:P(OEGMA-co-LMA) hybrid systems were successfully formulated and the most prominent factors influencing their thermodynamic, physicochemical, and toxicological properties were investigated. Our results indicate that self-assembly is pivotal for hybrid systems performance and is mediated via random topology of copolymer, lipid composition, hydrophilic to hydrophobic balance, and lipid to polymer ratio. Having in mind fast clinical translation, we hope this work to contribute to a design road map for efficient lipid/copolymer nanostructure development.
Τίτλος πηγής δημοσίευσης:	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Τόμος/Κεφάλαιο:	684
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φαρμακευτική τεχνολογία[EN] Pharmaceutical technology [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	hybrid nanoparticles lipids random copolymer self-assembly lipid to polymer ratio
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.colsurfa.2023.133015
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο