Εξειδίκευση τύπου :	Άρθρο σε περιοδικό τύπο
Τίτλος:	PEO-b-PCL/Tween 80/cyclodextrin systems: from bioinspired fabrication to possible nasal administration of ropinirole hydrochloride
Δημιουργός/Συγγραφέας:	Saitani, Elmina-Marina Pippa, Natassa Perinelli, Diego Romano Forys, Aleksander Papakyriakopoulou, Paraskevi Lagopati, Nefeli Bonacucina, Giulia Trzebicka, Barbara Gazouli, Maria [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Valsami, Georgia
Ημερομηνία:	2024-07-10
Γλώσσα:	Αγγλικά
DOI:	10.1039/d4tb00489b
Άλλο:	38804576
Περίληψη:	In this study, we designed and developed systems composed of poly(ethylene-oxide)-b-poly(ε-caprolactone) block copolymers of different molecular weights and compositions, non-ionic surfactant, and cyclodextrins. The innovation of this study lies in the combination of these diverse biomaterials to create biomimetic and bioinspired drug delivery supramolecular structures. The systems were formed by the thin-film hydration method. Extensive physicochemical and morphological characterization was conducted using differential scanning calorimetry, light scattering techniques, microcalorimetry analysis, high-resolution ultrasound spectroscopy, surface tension measurements, fluorescence spectroscopy, cryogenic transmission electron microscopy images, and in vitro cytotoxicity evaluation. These innovative hybrid nanoparticles were found to be attractive candidates as drug delivery systems with unique properties by encompassing the physicochemical and thermotropic properties of both classes of materials. Subsequently, Ropinirole hydrochloride was used as a model drug for the purpose of this study. These systems showed a high RH content (%), and in vitro diffusion experiments revealed that more than 90% of the loading dose was released under pH and temperature conditions that simulate the conditions of the nasal cavity. Promising drug release performance was observed with all tested formulations, worth further investigation to explore both ex vivo permeation through the nasal mucosa and in vivo performance in an experimental animal model.
Τίτλος πηγής δημοσίευσης:	Journal of materials chemistry. B
Τόμος/Κεφάλαιο:	12
Τεύχος:	27
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	humans drug liberation particle size drug carriers animals nanoparticles administration, intranasal cyclodextrins indoles polyesters polyethylene glycols
Όροι και προϋποθέσεις δικαιωμάτων:	This article is Open Access. Is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1039/D4TB00489B
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο