Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Multi-Responsive Amphiphilic Hyperbranched Poly[(2-dimethyl aminoethyl methacrylate)-co-(benzyl methacrylate)]copolymers: Self-Assembly and Curcumin Encapsulation in Aqueous Media
Δημιουργός/Συγγραφέας:	Ginosati, Foteini Vagenas, Dimitrios Gerardos, Angelica Maria [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Ημερομηνία:	2025-01-23
Γλώσσα:	Αγγλικά
ISSN:	1996-1944
DOI:	10.3390/ma18030513
Άλλο:	39942180
Περίληψη:	In this study, we report the synthesis of amphiphilic hyperbranched poly[(2-dimethylaminoethyl methacrylate)-co-(benzyl methacrylate)] statistical copolymers with two different stoichiometric compositions using the reversible addition-fragmentation chain transfer polymerization (RAFT) technique. The selection of monomers was made to incorporate a pH and thermoresponsive polyelectrolyte (DMAEMA) component and a hydrophobic component (BzMA) to achieve amphiphilicity and study the effects of architecture and environmental factors on the behavior of the novel branched copolymers. Molecular characterization was performed through size exclusion chromatography (SEC) and spectroscopic characterization techniques (1H-NMR and FT-IR). The self-assembly behavior of the hyperbranched copolymers in aqueous media, in response to variations in pH, temperature, and ionic strength, was studied using dynamic light scattering (DLS), electrophoretic light scattering (ELS), and fluorescence spectroscopy (FS). Finally, the efficacy of the two novel copolymers to encapsulate curcumin (CUR), a hydrophobic, polyphenolic drug with proven anti-inflammatory and fluorescence properties, was established. Its encapsulation was evaluated through DLS, UV-Vis, and fluorescence measurements, investigating the change of hydrodynamic radius of the produced mixed copolymer-CUR nanoparticles in each case and their fluorescence emission properties.
Τίτλος πηγής δημοσίευσης:	Materials (Basel, Switzerland)
Τόμος/Κεφάλαιο:	18
Τεύχος:	3
Θεματική Κατηγορία:	[EL] Φασματοσκοπία[EN] Spectroscopy [EL] Βιοιατρική μηχανική. Ηλεκτρονική. Ενοργάνιση[EN] Biomedical engineering. Electronics. Instrumentation
Λέξεις-Κλειδιά:	RAFT polymerization amphiphilic hyperbranched statistical copolymers curcumin encapsulation light scattering self-assembly
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/ma18030513
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο