Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Tumor-infiltrating lymphocytes in cancer immunotherapy: from chemotactic recruitment to translational modeling
Δημιουργός/Συγγραφέας:	Kraja, Fatjona Pupuleku Jurisic, Vladimir B Hromić-Jahjefendić, Altijana Rossopoulou, Nafsika [EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodora Mirjacic Martinovic, Katarina De Las Rivas, Javier Diaconu, Carmen Cristina Szöőr, Árpád
Ημερομηνία:	2025
ISSN:	1664-3224
DOI:	10.3389/fimmu.2025.1601773
Άλλο:	40475782
Περίληψη:	Tumor-infiltrating lymphocytes (TILs) are a diverse population of immune cells that play a central role in tumor immunity and have emerged as critical mediators in cancer immunotherapy. This review explores the phenotypic and functional diversity of TILs-including CD8+ cytotoxic T cells, CD4+ helper T cells, regulatory T cells, B cells, and natural killer (NK) cells-and their dynamic interactions within the tumor microenvironment (TME). While TILs can drive tumor regression, their activity is often hindered by immune checkpoint signaling, metabolic exhaustion, and stromal exclusion. We highlight TIL recruitment, activation, and polarization mechanisms, focusing on chemokine gradients, endothelial adhesion molecules, and dendritic cell-mediated priming. Special emphasis is placed on preclinical models that evaluate TIL function, including 3D tumor spheroids, organoid co-cultures, syngeneic mouse models, and humanized systems. These provide valuable platforms for optimizing TIL-based therapies. Furthermore, we examine the prognostic and predictive value of TILs across cancer types, their role in adoptive cell therapy, and the challenges of translating preclinical success into clinical efficacy. Emerging technologies such as single-cell sequencing, neoantigen prediction, and biomaterial platforms are transforming our understanding of TIL biology and enhancing their therapeutic potential. Innovative strategies-ranging from genetic engineering and combination therapies to targeted modulation of the TME-are being developed to overcome resistance mechanisms and improve TIL persistence, infiltration, and cytotoxicity. This review integrates current advances in TIL research and therapy, offering a comprehensive foundation for future clinical translation. TILs hold significant promise as both biomarkers and therapeutic agents, and with continued innovation, they are poised to become a cornerstone of personalized cancer immunotherapy.
Τίτλος πηγής δημοσίευσης:	Frontiers in immunology
Τόμος/Κεφάλαιο:	16
Θεματική Κατηγορία:	[EL] Ανοσολογία[EN] Immunology [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Κυτταρολογία[EN] Cytology [EL] Μοριακή Βιολογία[EN] Molecular Biology
Λέξεις-Κλειδιά:	adoptive cell transfer experimental models immunotherapy tumor microenvironment tumor-infiltrating lymphocytes
Χρηματοδότης:	National Research, Development and Innovation Office, Hungary European Union European Regional Development Fund University of Debrecen Program for Scientific Publication
EU Grant identifier:	OTKA K143771 FK132773 GINOP-2.3.3-15-2016-00003
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 Kraja, Jurisic, Hromić-Jahjefendić, Rossopoulou, Katsila, Mirjacic Martinovic, De Las Rivas, Diaconu and Szöőr.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3389/fimmu.2025.1601773
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο