Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Detection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling
Δημιουργός/Συγγραφέας:	Govind, Shelia Lang, Pierre Olivier Bürkle, Alexander Moreno-Villanueva, María Franceschi, Claudio Capri, Miriam Bernard, Jurgen Weinberger, Birgit Grubeck-Loebenstein, Beatrix Fiegl, Simone [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Sikora, Ewa Jansen, Eugène Dollé, Martijn E T Grune, Tilman Breusing, Nicolle Aspinall, Richard
Ημερομηνία:	2024-11-29
Γλώσσα:	Αγγλικά
ISSN:	1742-4933
DOI:	10.1186/s12979-024-00490-9
Άλλο:	39609853
Περίληψη:	Decline in immune function with age has been studied extensively, but approaches to immune restoration have been hampered by the lack of simple methods of identifying individuals whose immune system is in decline. Our approach has been to identify individuals whose immune decline has led to a loss of control of common latent viral infections and their consequent reactivation. Viruses excreted in urine were detected and quantified and we believe this approach could provide a 'surrogate marker' for identifying immune compromised individuals. Here we report the detection of human herpes virus (HHV) 5, 6a, 6b and 7 in the urine of healthy individuals over a wide age range and their correlation with T cell receptor excision circle (TREC) data. The results did not show a clear correlation between TREC values and the detection of individual specific viruses or viral load values when measured singly. However, a correlation was found between low TREC values and the detection of several different human herpes viruses in the urine in males. We present evidence suggesting that for males, the detection of three or more different human herpes viruses in the urine could identify individuals with declining immune function as evidenced by their significantly lower TREC levels.
Τίτλος πηγής δημοσίευσης:	Immunity & ageing : I & A
Τόμος/Κεφάλαιο:	21
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Ιολογία[EN] Virology [EL] Ανοσολογία[EN] Immunology [EL] Εσωτερική ιατρική[EN] Internal medicine
Λέξεις-Κλειδιά:	Human Herpes Virus T cell receptor excision circles
Χρηματοδότης:	European Commission
EU Grant:	MARK-AGE
EU Grant identifier:	200880
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s) 2024
Όροι και προϋποθέσεις δικαιωμάτων:	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1186/s12979-024-00490-9
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο