Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Liposome-Based Interventions in Knee Osteoarthritis
Δημιουργός/Συγγραφέας:	[EL] Μήτσου, Ευγενία[EN] Mitsou, Evgenia Klein, Jacob
Ημερομηνία:	2025-04
Γλώσσα:	Αγγλικά
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.202410060
Άλλο:	40143645
Περίληψη:	Osteoarthritis (OA) is the most common degenerative disease of the joints, causing significant disability and socio-economic burden in the aging population. Simultaneously, however, it is a common occurrence in younger individuals, initiated by joint injuries or obesity alongside other factors. Intravenous and oral pharmaceutical OA management have both been associated with systemic adverse effects, thereby resulting in a growing interest in intra-articular (IA) treatment. IA-administered drugs circumvent the requirement for high dosage, offering immediate access to the site of interest while minimizing any unfavorable effects. Nonetheless, IA-injected drugs, administered in their free form, present low retention time in the knee joint raising the need for multiple injection dosage regimens, while their capability to target the cartilage or specific cell populations is limited. Liposomes, due to their unique characteristics and tunable nature, have proven to be excellent candidates for the management of knee OA. This review explores the last decade's research on the efficacy of various IA liposomal formulations, investigating their multifaceted properties as pharmaceutical carriers, lubricating agents, and a basis for combinatorial approaches paving the way to novel treatment solutions for OA.
Τίτλος πηγής δημοσίευσης:	Small (Weinheim an der Bergstrasse, Germany)
Τόμος/Κεφάλαιο:	21
Τεύχος:	17
Θεματική Κατηγορία:	[EL] Φαρμακευτική[EN] Pharmacy and materia medica [EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Βιοχημεία[EN] Biochemistry [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	drug delivery intra‐articular administration knee osteoarthritis liposomes lubrication
Χρηματοδότης:	European Research Council McCutchen Foundation Israel Science Foundation Azrieli Foundation
EU Grant:	743 016 1229/20
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Author(s). Small published by Wiley-VCH GmbH
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1002/smll.202410060
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο