Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	ProteoSeeker: A Feature-Rich Metagenomic Analysis Tool for Accessible and Comprehensive Metagenomic Exploration
Δημιουργός/Συγγραφέας:	Filis, Georgios Bezantakou, Dimitra Rigkos, Konstantinos Noti, Despina Saridis, Pavlos Zarafeta, Dimitra [EL] Σκρέτας, Γιώργος[EN] Skretas, George
Ημερομηνία:	2025-03-25
Γλώσσα:	Αγγλικά
ISSN:	2198-3844 2198-3844
DOI:	10.1002/advs.202414877
Άλλο:	40130725
Περίληψη:	The vast majority of microbial diversity remains unculturable, limiting access to novel biotechnological resources. Advances in metagenomics have expanded the understanding of microbial communities, yet targeted protein discovery remains challenging. This study introduces ProteoSeeker, a command-line tool for streamlined metagenomic protein identification and annotation. ProteoSeeker operates in two primary modes: i) Seek mode, which screens the proteins according to user-defined protein families, and ii) Taxonomy mode, which uncovers the taxonomy of the host organisms. By automating key steps, ProteoSeeker reduces computational complexity, enabling time-efficient and comprehensive metagenomic analysis for both specialized and nonspecialized users. The efficiency of ProteoSeeker to achieve targeted enzyme discovery is demonstrated by identifying extremophilic enzymes with desired biochemical features, such as amylases for starch hydrolysis and carbonic anhydrases for CO₂ capture applications. By democratizing functional metagenomics, ProteoSeeker is anticipated to accelerate biotechnology, synthetic biology, and biomedical research and innovation.
Τίτλος πηγής δημοσίευσης:	Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Θεματική Κατηγορία:	[EL] Βιοτεχνολογία[EN] Biotechnology [EL] Βιοπληροφορική[EN] Bioinformatics [EL] Μοριακή Βιολογία[EN] Molecular Biology [EL] Μικροβιολογία[EN] Microbiology
Λέξεις-Κλειδιά:	bioinformatics pipeline command‐line tool metagenomic analysis protein discovery shotgun sequencing taxonomic analysis whole‐genome sequencing
Κάτοχος πνευματικών δικαιωμάτων:	© 2025 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1002/advs.202414877
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο