Qualified type:	Scientific journal article
Title:	Natural Compounds for Bone Remodeling: A Computational and Experimental Approach Targeting Bone Metabolism-Related Proteins
Creator:	Loukas, Alexandros-Timotheos Papadourakis, Michail Panagiotopoulos, Vasilis Zarmpala, Apostolia Chontzopoulou, Eleni Christodoulou, Stephanos [EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodora [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis Matsoukas, Minos-Timotheos
Date:	2024-05-06
Language:	English
ISSN:	1422-0067
DOI:	10.3390/ijms25095047
Other:	38732267
Abstract:	Osteoporosis, characterized by reduced bone density and increased fracture risk, affects over 200 million people worldwide, predominantly older adults and postmenopausal women. The disruption of the balance between bone-forming osteoblasts and bone-resorbing osteoclasts underlies osteoporosis pathophysiology. Standard treatment includes lifestyle modifications, calcium and vitamin D supplementation and specific drugs that either inhibit osteoclasts or stimulate osteoblasts. However, these treatments have limitations, including side effects and compliance issues. Natural products have emerged as potential osteoporosis therapeutics, but their mechanisms of action remain poorly understood. In this study, we investigate the efficacy of natural compounds in modulating molecular targets relevant to osteoporosis, focusing on the Mitogen-Activated Protein Kinase (MAPK) pathway and the gut microbiome's influence on bone homeostasis. Using an in silico and in vitro methodology, we have identified quercetin as a promising candidate in modulating MAPK activity, offering a potential therapeutic perspective for osteoporosis treatment.
Reference title:	International journal of molecular sciences
Volume/Chapter:	25
Issue:	9
Subject:	[EL] Φυσιολογία[EN] Physiology [EL] Δημόσια υγεία. Υγιεινή. Προληπτική ιατρική[EN] Public health. Hygiene. Preventive medicine [EL] Βιοχημεία[EN] Biochemistry
Keywords:	osteoporosis natural compounds molecular docking molecular dynamics simulations bone metabolism quercetin MAPKs
Funding stream:	Competitiveness, Entrepreneurship and Innovation
Identifier of funding stream:	T2EDK-03847
Rights holder:	© 2024 by the authors. Licensee MDPI, Basel, Switzerland.
Rights terms of use:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Publisher link:	https://www.mdpi.com/1422-0067/25/9/5047
Appears in Collections:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο