Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Antimicrobial Potency of Fmoc-Phe-Phe Dipeptide Hydrogels with Encapsulated Porphyrin Chromophores Is a Promising Alternative in Antimicrobial Resistance
Δημιουργός/Συγγραφέας:	Apostolidou, Chrysanthi Pinelopi Kokotidou, Chrysoula Platania, Varvara Nikolaou, Vasilis Landrou, Georgios Nikoloudakis, Emmanouil [EL] Χαραλαμπίδης, Γεώργιος[EN] Charalambidis, Georgios Chatzinikolaidou, Maria Coutsolelos, Athanassios G Mitraki, Anna
Ημερομηνία:	2024-02-16
Γλώσσα:	Αγγλικά
ISSN:	2218-273X
DOI:	10.3390/biom14020226
Άλλο:	38397463
Περίληψη:	Antimicrobial resistance (AMR) poses a significant global health risk as a consequence of misuse of antibiotics. Owing to the increasing antimicrobial resistance, it became imperative to develop novel molecules and materials with antimicrobial properties. Porphyrins and metalloporphyrins are compounds which present antimicrobial properties especially after irradiation. As a consequence, porphyrinoids have recently been utilized as antimicrobial agents in antimicrobial photodynamic inactivation in bacteria and other microorganisms. Herein, we report the encapsulation of porphyrins into peptide hydrogels which serve as delivery vehicles. We selected the self-assembling Fmoc-Phe-Phe dipeptide, a potent gelator, as a scaffold due to its previously reported biocompatibility and three different water-soluble porphyrins as photosensitizers. We evaluated the structural, mechanical and in vitro degradation properties of these hydrogels, their interaction with NIH3T3 mouse skin fibroblasts, and we assessed their antimicrobial efficacy against Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria. We found out that the hydrogels are cytocompatible and display antimicrobial efficiency against both strains with the zinc porphyrins being more efficient. Therefore, these hydrogels present a promising alternative for combating bacterial infections in the face of growing AMR concerns.
Τίτλος πηγής δημοσίευσης:	Biomolecules
Τόμος/Κεφάλαιο:	14
Τεύχος:	2
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Χημική τεχνολογία[EN] Chemical technolgy
Λέξεις-Κλειδιά:	Porphyrins Hydrogels Self-assembling peptides Antimicrobial activity Encapsulation Controlled release Photodynamic inactivation
Χρηματοδοτικό πρόγραμμα:	Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE ARCHERS HFRI PhD Fellowship Enhancing Human Resources Research Potential by undertaking a Doctoral Research, Sub-action 2
Αναγνωριστικό χρηματοδοτικού προγράμματος:	T1EDK—01504 390
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/biom14020226
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο