Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	Rational drug design using integrative structural biology
Δημιουργός/Συγγραφέας:	Chegkazi M.S. Mamais M. Sotiropoulou A.I. [EL] Χρυσίνα, Ευαγγελία Δ.[EN] Chrysina, Evangelia D.
Εκδότης:	Humana Press Inc.
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	1064-3745
DOI:	10.1007/978-1-4939-8630-9_6
Άλλο:	PubMed ID: 30039403
Περίληψη:	Modern drug discovery and design approaches rely heavily on high-throughput methods and state-of-theart infrastructures with robotic facilities and sophisticated platforms. However, the anticipated research output that would eventually lead to new drugs with minimal or no side effects to the market has not been achieved. Despite the vast amount of information generated, very little is converted to knowledge and even less is capitalized for cross-discipline research actions. Therefore, the need for re-launching rational approaches has become apparent. Here we present an overview of the new trends in rational drug design using integrative structural biology with emphasis on X-ray protein crystallography and small molecules as ligands. With the aim to increase researchers’ awareness on the available possibilities to perform front line research, we also underline the benefits and enhanced prospects offered to the scientific community, through access to research infrastructures.
Τίτλος πηγής δημοσίευσης:	Methods in Molecular Biology
Τόμος/Κεφάλαιο:	1824
Σελίδες:	1
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Χημεία (Γενικά)[EN] Chemistry (General)
Λέξεις-Κλειδιά:	Bioinformatics Structural biology Structure-based drug design X-ray protein crystallography
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© Springer Science+Business Media, LLC, part of Springer Nature 2018.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο