Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Sugar-derived AGEs accelerate pharyngeal pumping rate and increase the lifespan of Caenorhabditis elegans
Δημιουργός/Συγγραφέας:	Papaevgeniou N. Hoehn A. Tur J.A. Klotz L.-O. Grune T. [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki
Εκδότης:	Taylor and Francis Ltd
Ημερομηνία:	2019
Γλώσσα:	Αγγλικά
ISSN:	1071-5762
DOI:	10.1080/10715762.2019.1661403
Άλλο:	PubMed ID: 31514551
Περίληψη:	All living organisms are normally undergoing aging. Dietary habits constitute the main environmental factor that may accelerate or decelerate this process. Advanced glycation end products (AGEs) are constituents of dietary products that are consumed daily, such as bread and milk. Although AGEs have been widely regarded as toxic agents, recent studies seem to contradict this view: they either find no adverse effects of AGEs or even attribute beneficial properties to them. The aim of our study was to investigate the effects of sugar-derived AGEs on organismal lifespan using as a model the nematode Caenorhabditis elegans. Exposure to sugar-derived AGEs prolonged the lifespan of wild type animals; this lifespan extension was accompanied by an enhanced pharyngeal pumping rate. We demonstrate that elevation of the pharyngeal pumping rate depends on W06A7.4 and eat-4 expression, as well as on daf-16, which encodes a FOXO family transcription factor. Our results suggest that sugar-derived AGEs modulate the lifespan of C. elegans at least in part through transcriptional regulation of pharyngeal pumping throughout the animals’ lifespan.
Τίτλος πηγής δημοσίευσης:	Free Radical Research
Τόμος/Κεφάλαιο:	53
Τεύχος:	sup1
Σελίδες:	1056-1067
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Advanced glycation end products aging C. elegans lifespan extension pharyngeal pumping
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Hybrid Gold
Σημειώσεις:	MIS 5002398, T1EDK-00353, T1EDK-01610; National Center for Research Resources, NCRR: NCRR; European Cooperation in Science and Technology, COST: NutRedOx-CA16112; Instituto de Salud Carlos III, ISCIII: CIBERobn CB12/03/30038; European Regional Development Fund, FEDER
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο