Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Amphiphilic poly(2-oxazoline) copolymers as self-assembled carriers for drug delivery applications
Δημιουργός/Συγγραφέας:	Vlassi E. [EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	Elsevier
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	0014-3057
DOI:	10.1016/j.eurpolymj.2016.10.034
Περίληψη:	The potential of poly(2-oxazoline) containing copolymers for drug delivery is discussed in this feature article. Advances in synthetic routes for 2-oxazoline copolymerization and chemical modification of biocompatible poly(2-oxazoline) copolymers allow the control of amphiphilic poly(2-oxazoline) copolymers at the molecular level. Thus macromolecular design dictates self-organization of poly(2-oxazoline) copolymers at the nano-scale into morphologically diverse, functional nanostructures in aqueous solutions, able to respond to changes caused by external stimuli and showing fine-tuned interactions, loading and release properties of encapsulated hydrophobic drugs and biological macromolecules. The latest advances in the use of poly(2-oxazoline) containing copolymers as carriers of hydrophobic drugs, therapeutic proteins/peptides and nucleic acids are presented through representative examples from recent literature. It can be safely concluded that nanocarriers based on poly(2-oxazoline) containing block copolymers show a great potential for applications in the biomedical field in the near future.
Τίτλος πηγής δημοσίευσης:	European Polymer Journal
Τόμος/Κεφάλαιο:	88
Σελίδες:	516-523
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	Bio-applications Copolymers Nanostructures Poly(2-oxazoline)s Self-assembly
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2016 Elsevier Ltd
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο