Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	TAF4b and Jun/Activating Protein-1 Collaborate to Regulate the Expression of Integrin alpha 6 and Cancer Cell Migration Properties
Δημιουργός/Συγγραφέας:	Kalogeropoulou, Margarita Voulgari, Angeliki Kostourou, Vassiliki Sandaltzopoulos, Raphael Dikstein, Rivka Davidson, Irwin Tora, Laszlo [EL] Πίντζας, Αλέξανδρος[EN] Pintzas, Alexander
Εκδότης:	American Association for Cancer Research
Τόπος έκδοσης:	Philadelphia
Ημερομηνία:	2010-04
Γλώσσα:	Αγγλικά
ISSN:	1541-7786
DOI:	10.1158/1541-7786.MCR-09-0159
Περίληψη:	The TAF4b subunit of the transcription factor IID, which has a central role in transcription by polymerase II, is involved in promoter recognition by selective recruitment of activators. The activating protein-1 (AP-1) family members participate in oncogenic transformation via gene regulation. Utilizing immunoprecipitation of endogenous protein complexes, we documented specific interactions between Jun family members and TATA box binding protein-associated factors (TAF) in colon HT29 adenocarcinoma cells. Particularly, TAF4b and c-Jun were found to colocalize and interact in the nucleus of advanced carcinoma cells and in cells with epithelial-to-mesenchymal transition (EMT) characteristics. TAF4b was found to specifically regulate the AP-1 target gene involved in EMT integrin alpha 6, thus altering related cellular properties such as migration potential. Using a chromatin immunoprecipitation approach in colon adenocarcinoma cell lines, we further identified a synergistic role for TAF4b and c-Jun and other AP-1 family members on the promoter of integrin alpha 6, underlining the existence of a specific mechanism related to gene expression control. We show evidence for the first time of an interdependence of TAF4b and AP-1 family members in cell type-specific promoter recognition and initiation of transcription in the context of cancer progression and EMT.
Τίτλος πηγής δημοσίευσης:	Molecular Cancer Research
Τόμος/Κεφάλαιο:	8
Τεύχος:	4
Σελίδες:	554-568
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Βιολογία (Γενικά)[EN] Biology (General)
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2010 AACR.
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο