Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Anti-ageing and rejuvenating effects of quercetin
Δημιουργός/Συγγραφέας:	[EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Kapeta, Suzanne Chinou, Ioanna Vassilatou, Katerina Papassideri, Issidora [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S.
Εκδότης:	Elsevier Inc.
Τόπος έκδοσης:	OXFORD
Ημερομηνία:	2010-10
Γλώσσα:	Αγγλικά
ISSN:	0531-5565
DOI:	10.1016/j.exger.2010.07.001
Περίληψη:	Homeostasis is a key feature of the cellular lifespan. Its maintenance influences the rate of ageing and it is determined by several factors, including efficient proteolysis. The proteasome is the major cellular proteolytic machinery responsible for the degradation of both normal and damaged proteins. Alterations of proteasome function have been recorded in various biological phenomena including ageing and replicative senescence. Proteasome activities and function are decreased upon replicative senescence, whereas proteasome activation confers enhanced survival against oxidative stress, lifespan extension and maintenance of the young morphology longer in human primary fibroblasts. Several natural compounds possess anti-ageing/anti-oxidant properties. In this study, we have identified quercetin (QUER) and its derivative, namely quercetin caprylate (QU-CAP) as a proteasome activator with anti-oxidant properties that consequently influence cellular lifespan, survival and viability of HFL-1 primary human fibroblasts. Moreover, when these compounds are supplemented to already senescent fibroblasts, a rejuvenating effect is observed. Finally, we show that these compounds promote physiological alterations when applied to cells (i.e. whitening effect). In summary, these data demonstrate the existence of naturally occurring anti-ageing products that can be effectively used through topical application.
Τίτλος πηγής δημοσίευσης:	Experimental Gerontology
Τόμος/Κεφάλαιο:	45
Τεύχος:	10
Σελίδες:	763-771
Λέξεις-Κλειδιά:	Quercetin Quercetin caprylate Anti-ageing Rejuvenation Proteasome Geriatrics & Gerontology
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2010 Elsevier Inc. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S0531556510002196?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.elsevier.com/locate/expgero
Σημειώσεις:	Special Issue SI
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο