Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population
Δημιουργός/Συγγραφέας:	Cianfruglia, Laura Fortunato, Carlo Badillo Pazmay, Gretta Veronica Bürkle, Alexander Moreno-Villanueva, María Grune, Tilman Weber, Daniela [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Friguet, Bertrand Petropoulos, Isabelle Piacenza, Francesco Cardelli, Maurizio Cecati, Monia Capri, Miriam Franceschi, Claudio Dollé, Martijn E T Jansen, Eugène Weinberger, Birgit Sikora, Ewa Debacq-Chainiaux, Florence Stuetz, Wolfgang Hurme, Mikko Slagboom, P Eline Bernhardt, Jürgen Talbot, Duncan Olivieri, Fabiola Malavolta, Marco Giacconi, Robertina
Ημερομηνία:	2025-07-30
Γλώσσα:	Αγγλικά
ISSN:	1389-5729 1573-6768
DOI:	10.1007/s10522-025-10288-x
Άλλο:	40736759
Περίληψη:	Cytomegalovirus (CMV) drives immunosenescence, while its reactivation is associated with inflammation and oxidative stress. This study investigates the interplay between CMV, oxidative stress and inflammation in a cohort of 2065 age-stratified individuals randomly recruited from the general population (RASIG), as part of the MARK-AGE study, to better understand the role of CMV in immunosenescence and its potential impact on age-related diseases. CMV IgG titers were associated with oxidative stress, antioxidant, and inflammatory biomarkers. Stepwise-linear regression identified positive associations with age, BMI, apolipoprotein J (ApoJ/Clu), ceruloplasmin, α-2-macroglobulin, proteasome peptidase activity, and malondialdehyde, and negative associations with α-tocopherol, selenium, and vitamin D. Notably, the associations with ApoJ/Clu and proteasome peptidase activity represent novel findings that point to a potential involvement of proteostasis dysregulation and cellular stress responses in CMV-related immune alterations. Quartile-based analyses revealed significantly lower antioxidant levels (α-tocopherol, selenium, ascorbic acid and vitamin D) and higher oxidative stress markers (plasma 8-isoprostanes, malondialdehyde) in the highest quartile (Q4) compared to lower quartiles. Inflammatory markers (homocysteine, ceruloplasmin and α-2-macroglobulin) ApoJ/Clu and proteasome peptidase activity were elevated in Q4. This group also exhibited a higher prevalence of cardiovascular diseases, hypertension, and diabetes. This study highlights a link between CMV IgG titers, oxidative stress, inflammation, and the prevalence of cardiovascular and metabolic diseases. Our findings suggest that CMV may contribute to immunosenescence through mechanisms involving redox imbalance and dysregulation of protein degradation pathways. Further research is needed to explore the role of CMV reactivation in aging, and its impact on age-related metabolic and cardiovascular diseases.
Τίτλος πηγής δημοσίευσης:	Biogerontology
Τόμος/Κεφάλαιο:	26
Τεύχος:	4
Θεματική Κατηγορία:	[EL] Ανοσολογία[EN] Immunology [EL] Γηριατρική[EN] Geriatrics [EL] Βιοχημεία[EN] Biochemistry [EL] Μοριακή Βιολογία[EN] Molecular Biology
Λέξεις-Κλειδιά:	Aging ApoJ/Clu CMV Inflammation Oxidative stress Proteasome Redox balance
Χρηματοδότης:	European Commission
Αναγνωριστικό χρηματοδοτικού προγράμματος:	No: 200880
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s), under exclusive licence to Springer Nature B.V. 2025
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1007/s10522-025-10288-x
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο