Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort
Δημιουργός/Συγγραφέας:	Schoissengeier, Vanessa Maqboul, Lina Weber, Daniela Grune, Tilman Bürkle, Alexander Moreno-Villaneuva, Maria Franceschi, Claudio Capri, Miriam Bernhard, Jürgen Toussaint, Olivier Debacq-Chainiaux, Florence Weinberger, Birgit [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Sikora, Ewa Dollé, Martijn Jansen, Eugène Slagboom, P Eline Hervonnen, Antti Hurme, Mikko Breusing, Nicolle Frank, Jan Bulmer, Andrew C Wagner, Karl-Heinz
Ημερομηνία:	2024-07-19
Γλώσσα:	Αγγλικά
ISSN:	25890042
DOI:	10.1016/j.isci.2024.110234
Άλλο:	39021797
Περίληψη:	Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.
Τίτλος πηγής δημοσίευσης:	iScience
Τόμος/Κεφάλαιο:	27
Τεύχος:	7
Θεματική Κατηγορία:	[EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology [EL] Γηριατρική[EN] Geriatrics [EL] Βιοχημεία[EN] Biochemistry [EL] Παθολογία[EN] Pathology [EL] Αναλυτική χημεία[EN] Analytical chemistry
Λέξεις-Κλειδιά:	human metabolism pathology public health
EU Grant:	MARK-AGE
EU Grant identifier:	P 32303 200880
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 The Authors. Published by Elsevier Inc.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.isci.2024.110234
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο