Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog
Δημιουργός/Συγγραφέας:	Magkouta, Sophia Veroutis, Dimitris Papaspyropoulos, Angelos Georgiou, Maria Lougiakis, Nikolaos Pippa, Natassa Havaki, Sophia Palaiologou, Anastasia Thanos, Dimitris-Foivos Kambas, Konstantinos Lagopati, Nefeli Boukos, Nikos Pouli, Nicole Marakos, Panagiotis Kotsinas, Athanassios Thanos, Dimitris Evangelou, Konstantinos Sampaziotis, Fotios Tamvakopoulos, Constantin [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Petty, Russell Kotopoulos, Nicholas Gorgoulis, Vassilis G
Ημερομηνία:	2025-01
Γλώσσα:	Αγγλικά
ISSN:	2662-8465
DOI:	10.1038/s43587-024-00747-4
Άλλο:	39730824
Περίληψη:	The emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging. Enhancing the selectivity of senolytic treatments toward senescent cells stands to reduce the adverse effects associated with existing senolytic interventions. Taking advantage of lipofuscin accumulation in senescent cells, we describe here the development of a highly efficient senolytic platform consisting of a lipofuscin-binding domain scaffold, which can be conjugated with a senolytic drug via an ester bond. As a proof of concept, we present the generation of GL392, a senolytic compound that carries a dasatinib senolytic moiety. Encapsulation of the GL392 compound in a micelle nanocarrier (termed mGL392) allows for both in vitro and in vivo (in mice) selective elimination of senescent cells via targeted release of the senolytic agent with minimal systemic toxicity. Our findings suggest that this platform could be used to enhance targeting of senotherapeutics toward senescent cells.
Τίτλος πηγής δημοσίευσης:	Nature aging
Τόμος/Κεφάλαιο:	5
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology [EL] Κυτταρολογία[EN] Cytology [EL] Γηριατρική[EN] Geriatrics
Λέξεις-Κλειδιά:	animals mice humans senotherapeutics dasatinib naphthalenes micelles cellular senescence azo compounds
EU Grant:	1st Call for H.F.R.I. Research Projects to support Faculty members and Researchers and the procurement of high-cost research equipment NKUA-SARG
EU Grant identifier:	2906; V.G.G. 70/3/8916 (V.G.G.) 2020ΣΕ01300001
Όροι και προϋποθέσεις δικαιωμάτων:	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1038/s43587-024-00747-4
Σημειώσεις:	The authors acknowledge support by the National Public Investment Program of the Ministry of Development and Investment/General Secretariat for Research and Technology, in the framework of the Flagship Initiative to address SARS-CoV-2 (2020ΣΕ01300001; V.G.G.); a Sonia & Nikos Kotopoulos Trust donation (V.G.G.); and Hellenic Foundation for Research and Innovation grant 3782 (V.G.G.). The cryo-EM work was supported by the Hellenic Foundation for Research and Innovation under the ‘1st Call for H.F.R.I. Research Projects to support Faculty members and Researchers and the procurement of high-cost research equipment’ (project no: 2906; V.G.G.); NKUA-SARG grant 70/3/8916 (V.G.G.); and the Foundation for Education and European Culture (A. Papaspyropoulos).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο