Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Therapeutic stapled peptides: Efficacy and molecular targets
Δημιουργός/Συγγραφέας:	Li, Yulei Wu, Minghao Fu, Yinxue Xue, Jingwen Yuan, Fei Qu, Tianci [EL] Ρισσάνου, Αναστασία[EN] Rissanou, Anastassia Wang, Yilin Li, Xiang Hu, Honggang
Ημερομηνία:	2024
Γλώσσα:	Αγγλικά
ISSN:	10436618
DOI:	10.1016/j.phrs.2024.107137
Περίληψη:	Peptide stapling, by employing a stable, preformed alpha-helical conformation, results in the production of peptides with improved membrane permeability and enhanced proteolytic stability, compared to the original peptides, and provides an effective solution to accelerate the rapid development of peptide drugs. Various reviews present peptide stapling chemistries, anchoring residues and one- or two-component cyclization, however, therapeutic stapled peptides have not been systematically summarized, especially focusing on various disease-related targets. This review highlights the latest advances in therapeutic peptide drug development facilitated by the application of stapling technology, including different stapling techniques, synthetic accessibility, applicability to biological targets, potential for solving biological problems, as well as the current status of development. Stapled peptides as therapeutic drug candidates have been classified and analysed mainly by receptor- and ligand-based stapled peptide design against various diseases, including cancer, infectious diseases, inflammation, and diabetes. This review is expected to provide a comprehensive reference for the rational design of stapled peptides for different diseases and targets to facilitate the development of therapeutic peptides with enhanced pharmacokinetic and biological properties.
Τίτλος πηγής δημοσίευσης:	Pharmacological Research
Τόμος/Κεφάλαιο:	203
Θεματική Κατηγορία:	[EL] Φαρμακευτική[EN] Pharmacy and materia medica [EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology
Λέξεις-Κλειδιά:	Staple peptide Therapeutic peptide drug α-helical peptide Targets
EU Grant identifier:	tsqn202306268 21807112 91849129 22077078 22207065 2019LJ003
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 The Authors. Published by Elsevier Ltd.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.phrs.2024.107137
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο