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https://hdl.handle.net/10442/19277
Εξειδίκευση τύπου : | Άρθρο σε επιστημονικό περιοδικό |
Τίτλος: | Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2 |
Δημιουργός/Συγγραφέας: | Buttari, Brigitta Tramutola, Antonella Rojo, Ana I [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Saha, Sarmistha Berry, Alessandra Giona, Letizia Miranda, Joana P Profumo, Elisabetta Davinelli, Sergio Daiber, Andreas Cuadrado, Antonio Di Domenico, Fabio |
Ημερομηνία: | 2025-01-13 |
Γλώσσα: | Αγγλικά |
ISSN: | 2218-273X |
DOI: | 10.3390/biom15010113 |
Άλλο: | 39858508 |
Περίληψη: | Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of cellular homeostasis, overseeing the expression of a wide array of genes involved in cytoprotective processes such as antioxidant and proteostasis control, mitochondrial function, inflammation, and the metabolism of lipids and glucose. The accumulation of misfolded proteins triggers the release, stabilization, and nuclear translocation of NRF2, which in turn enhances the expression of critical components of both the proteasomal and lysosomal degradation pathways. This process facilitates the clearance of toxic protein aggregates, thereby actively maintaining cellular proteostasis. As we age, the efficiency of the NRF2 pathway declines due to several factors including increased activity of its repressors, impaired NRF2-mediated antioxidant and cytoprotective gene expression, and potential epigenetic changes, though the precise mechanisms remain unclear. This leads to diminished antioxidant defenses, increased oxidative damage, and exacerbated metabolic dysregulation and inflammation-key contributors to age-related diseases. Given NRF2's role in mitigating proteotoxic stress, the pharmacological modulation of NRF2 has emerged as a promising therapeutic strategy, even in aged preclinical models. By inducing NRF2, it is possible to mitigate the damaging effects of oxidative stress, metabolic dysfunction, and inflammation, thus reducing protein misfolding. The review highlights NRF2's therapeutic implications for neurodegenerative diseases and cardiovascular conditions, emphasizing its role in improving proteostasis and redox homeostasis Additionally, it summarizes current research into NRF2 as a therapeutic target, offering hope for innovative treatments to counteract the effects of aging and associated diseases. |
Τίτλος πηγής δημοσίευσης: | Biomolecules |
Τόμος/Κεφάλαιο: | 15 |
Τεύχος: | 1 |
Θεματική Κατηγορία: | [EL] Βιοχημεία[EN] Biochemistry [EL] Μοριακή Βιολογία[EN] Molecular Biology [EL] Γηριατρική[EN] Geriatrics |
Λέξεις-Κλειδιά: | NRF2 aging neurodegeneration oxidative stress proteostasis redox balance humans animals oxidative stress antioxidants NF-E2-Related Factor 2 proteostasis oxidation-reduction aging |
EU Grant identifier: | PID2019-110061RB-I00 PID-2021-122766OB-100 PDC2021-121421-I00 PDC2022-133765-I00 CB06/05/0010 P2022/BMD-7230 RM12117A2EC1C9E4 RM11916B78D5711A RG1181642744DF59 2280_2023b |
Κάτοχος πνευματικών δικαιωμάτων: | : © 2025 by the authors. Licensee MDPI, Basel, Switzerland. |
Όροι και προϋποθέσεις δικαιωμάτων: | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/). |
Ηλεκτρονική διεύθυνση στον εκδότη (link): | https://doi.org/10.3390/biom15010113 |
Εμφανίζεται στις συλλογές: | Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο
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