Παρακαλώ χρησιμοποιήστε αυτό το αναγνωριστικό για να παραπέμψετε ή να δημιουργήσετε σύνδεσμο προς αυτό το τεκμήριο: https://hdl.handle.net/10442/19277
Export to:   BibTeX  | EndNote  | RIS
Εξειδίκευση τύπου : Άρθρο σε επιστημονικό περιοδικό
Τίτλος: Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2
Δημιουργός/Συγγραφέας: Buttari, Brigitta
Tramutola, Antonella
Rojo, Ana I
[EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Nikisemantics logo
Saha, Sarmistha
Berry, Alessandra
Giona, Letizia
Miranda, Joana P
Profumo, Elisabetta
Davinelli, Sergio
Daiber, Andreas
Cuadrado, Antonio
Di Domenico, Fabio
Ημερομηνία: 2025-01-13
Γλώσσα: Αγγλικά
ISSN: 2218-273X
DOI: 10.3390/biom15010113
Άλλο: 39858508
Περίληψη: Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of cellular homeostasis, overseeing the expression of a wide array of genes involved in cytoprotective processes such as antioxidant and proteostasis control, mitochondrial function, inflammation, and the metabolism of lipids and glucose. The accumulation of misfolded proteins triggers the release, stabilization, and nuclear translocation of NRF2, which in turn enhances the expression of critical components of both the proteasomal and lysosomal degradation pathways. This process facilitates the clearance of toxic protein aggregates, thereby actively maintaining cellular proteostasis. As we age, the efficiency of the NRF2 pathway declines due to several factors including increased activity of its repressors, impaired NRF2-mediated antioxidant and cytoprotective gene expression, and potential epigenetic changes, though the precise mechanisms remain unclear. This leads to diminished antioxidant defenses, increased oxidative damage, and exacerbated metabolic dysregulation and inflammation-key contributors to age-related diseases. Given NRF2's role in mitigating proteotoxic stress, the pharmacological modulation of NRF2 has emerged as a promising therapeutic strategy, even in aged preclinical models. By inducing NRF2, it is possible to mitigate the damaging effects of oxidative stress, metabolic dysfunction, and inflammation, thus reducing protein misfolding. The review highlights NRF2's therapeutic implications for neurodegenerative diseases and cardiovascular conditions, emphasizing its role in improving proteostasis and redox homeostasis Additionally, it summarizes current research into NRF2 as a therapeutic target, offering hope for innovative treatments to counteract the effects of aging and associated diseases.
Τίτλος πηγής δημοσίευσης: Biomolecules
Τόμος/Κεφάλαιο: 15
Τεύχος: 1
Θεματική Κατηγορία: [EL] Βιοχημεία[EN] Biochemistrysemantics logo
[EL] Μοριακή Βιολογία[EN] Molecular Biologysemantics logo
[EL] Γηριατρική[EN] Geriatricssemantics logo
Λέξεις-Κλειδιά: NRF2
aging
neurodegeneration
oxidative stress
proteostasis
redox balance
humans
animals
oxidative stress
antioxidants
NF-E2-Related Factor 2
proteostasis
oxidation-reduction
aging
EU Grant identifier: PID2019-110061RB-I00
PID-2021-122766OB-100
PDC2021-121421-I00
PDC2022-133765-I00
CB06/05/0010
P2022/BMD-7230
RM12117A2EC1C9E4
RM11916B78D5711A
RG1181642744DF59
2280_2023b
Κάτοχος πνευματικών δικαιωμάτων: : © 2025 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link): https://doi.org/10.3390/biom15010113
Εμφανίζεται στις συλλογές:Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο

Αρχεία σε αυτό το τεκμήριο:
Αρχείο Περιγραφή ΣελίδεςΜέγεθοςΜορφότυποςΈκδοσηΆδεια
Buttari et al_2025_biomolecules_biom15010113.pdfopen access article1.12 MBAdobe PDFΔημοσιευμένη/του ΕκδότηccbyΔείτε/ανοίξτε